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Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,

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Presentation on theme: "Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka,"— Presentation transcript:

1 Surface Treatment of Flexor Tendon Autografts with Carbodiimide-Derivatized Hyaluronic Acid by Chunfeng Zhao, Yu-Long Sun, Peter C. Amadio, Toshikazu Tanaka, Anke M. Ettema, and Kai-Nan An J Bone Joint Surg Am Volume 88(10):2181-2191 October 1, 2006 ©2006 by The Journal of Bone and Joint Surgery, Inc.

2 Carboxyl groups in the hyaluronic acid (HA) are activated by EDC to form O-acylisoureas, which bind to the amino groups on the tendon surface. Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181- 2191 ©2006 by The Journal of Bone and Joint Surgery, Inc.

3 Illustration of the proximal suture technique. Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181- 2191 ©2006 by The Journal of Bone and Joint Surgery, Inc.

4 Work-of-flexion tester. 1 = actuator, 2 = load transducer, 3 = specimen, 4 = two metal beads in the middle phalanx, 5 = metal pin in the distal phalanx, 6 = metal pin in the proximal phalanx, 7 = weight, and 8 = frame. Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181- 2191 ©2006 by The Journal of Bone and Joint Surgery, Inc.

5 Image obtained with fluoroscopy during testing. Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181- 2191 ©2006 by The Journal of Bone and Joint Surgery, Inc.

6 The work of flexion normalized according to the proximal and distal interphalangeal joint angle (normalized work of flexion) in the normal, cd-HA-treated, and saline-solution-treated groups at one, three, and six weeks. Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181- 2191 ©2006 by The Journal of Bone and Joint Surgery, Inc.

7 The gliding resistance in the normal, cd-HA-treated, and saline-solution-treated groups at one, three, and six weeks. Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181- 2191 ©2006 by The Journal of Bone and Joint Surgery, Inc.

8 The staining intensity of the cd-HA and saline-solution-treated tendon grafts at one, three, and six weeks. Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181- 2191 ©2006 by The Journal of Bone and Joint Surgery, Inc.

9 A: cd-HA-treated tendon graft harvested at six weeks, showing a smooth surface without adhesions to the flexor sheath. Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181- 2191 ©2006 by The Journal of Bone and Joint Surgery, Inc.

10 A: cd-HA-treated tendon graft harvested at six weeks, showing a smooth surface under scanning electron microscopy (×30). Chunfeng Zhao et al. J Bone Joint Surg Am 2006;88:2181- 2191 ©2006 by The Journal of Bone and Joint Surgery, Inc.


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