1. www.aids2014.org Towards a Science of Community Engagement in Biomedical HIV Prevention Trials: Towards a Science of Community Engagement in Biomedical HIV Prevention Trials: An Embedded Multiple Case Study in Canada, India, South Africa and Thailand Newman PA, Rubincam CC, Chuang D-M, Lindegger G, Slack C, Chakrapani V, Shunmugam M, Tepjan S, Roungprakhon S, & Canadian HIV Vaccine Initiative Team Background Community stakeholder engagement (SE) is foundational to fair & ethically conducted biomedical HIV prevention trials Scant empirical research has addressed SE To identify cross-cutting & site specific challenges & facilitators of SE in global HIV prevention trials Methods From 2009-2012 we conducted an embedded exploratory case study with a multiple case design (n=235)

2. www.aids2014.org Multiple Case Study Design CSO representatives Community leaders & advocates Community leaders & advocates Former trial participants Former trial participants Service providers Service providers CasesSubsystemsDecomposition Community members Community members New Conception New Conception of Cases of Cases Synthesis Clinical trialists  Ensuring trial literacy  Addressing mistrust  Processes of meaningful stakeholder engagement Bangkok, Thailand Chennai, India Durban, S. Africa Toronto, Canada

3. www.aids2014.org Conclusions Trial literacy: Ensure understanding among community stakeholders of complex trial concepts Historically-based mistrust among local communities Ethical integrity: explore how trials can best meet ethical obligations (e.g. ancillary services, post-trial care) Clear & transparent communication between researchers & trial participants Autonomy & independent decision-making of CABs/CBOs must be balanced with need for training & support