1. Treatment-Resistant Depression Doug Maurer, DO, MPH, FAAFP Program Director Faculty Development Fellowship

2. Objectives Defined treatment-resistant depression Reviewed the STAR*D trial Discussed pharmacologic and non-pharmacologic therapies

3. Treatment-Resistant Depression What is it? How do you currently manage it? We will hear a sample 2 minutes

4. Definition Depression resistant to two trials of antidepressants from different pharmacologic classes

5. Depression Cases Four cases based on STAR*D 15 min max of small group work 8 min max to brief the larger group Delegate questions within your group Delegate a scribe and spokesperson

6. Take Home Points 1/3 will remit with optimized SSRI Remission decreases with each treatment Time to remission may take up to 14 wks Different SSRI or non-SSRI reasonable tx Augmentation with bupropion or buspirone reasonable tx

7. Objectives Defined treatment-resistant depression Reviewed the STAR*D trial Discussed pharmacologic and non-pharmacologic therapies

8. Questions?