1. Clinical and histopathological correlations in rhinosinusitis Student: Blebea Cristina Conferentiar: Muhlfay Gheorghe Assistant: Lostun Gabriel

2.  Rhinosinusitis is a common and well- recognized clinical syndrome that affects a significant percentage of the patients from a Otorhinolaringology Department. Functional endoscopic sinus surgery (FESS) is now a well established strategy for the treatment of chronic rhinosinusitis(CRS) unresponsive to medical treatment.

3.  The objective of this study was to assess the correlation between histological and clinical diagnosis in rhinosinusitis, by evaluating the results of histopathological examination of postoperative material from FESS.

4.  This study is a retrospective analysis based on patients who underwent FESS over a 5 years period.  The analysis covered 673 results of routine postoperative histopathological examination material from Targu-Mures County Hospital's Department of Otorhinolaringology who underwent surgical procedures between the years 2009-2013.  The histopathological examination was conducted in Hematoxylin and Eosin and PAS staining in Targu-Mures County Hospital's Morphopathology Department.

5.  Having the ethical approval from University of Medicine and Pharmacy Tirgu-Mures, demographic data were analyzed via Chi- Square test and ROC curves using MedCalc. A p value of less than 0.05 considered significant.

6. Number of patients673 Mean age46,9 Minimum age5 Maximum87 SD16,46

9. 2 Special aspects

10. Fungal rhinosinusitis

11. Schneider papilloma

12.  The strong correlation between clinical inspection and pathological diagnosis of FESS Is histological confirmation needed?

13.  The low sensitivity of clinical diagnosis of Schneider papilloma can be reason to perform routine histopathological examination of FESS.

14.  The close correlation between clinical inspection and histopathology outcomes indicates that in pacients with suspected CRS with or without NP histopathology has little to no clinical value.  It might be considered the improvement of diagnosing the inverted papilloma

15.  Fokkens, WJ; Lund, VJ; Mullol, J; Bachert, C; Alobid, I; Baroody, F;... Wormald, PJ; (2012) EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists.  The Royal College of Pathologists (2005) Histopathology of limited or no clinical value, 2nd edn. RCPath, London, UK.  Kale SU, Mohite U, Rowlands D, Drake-Lee AB (2001) Clinical and histopathological correlation of nasal polyps: are there any surprises? Clin Otolaryngol Allied Sci 26(4):321–323  Hassid, Sergio. "[Rhinosinusitis]." Revue médicale de Bruxelles 34.4 (2013): 257-261.  Van den Boer, Cindy, Guy Brutel, and Nico de Vries. "Is routine histopathological examination of FESS material useful?." European Archives of Oto-Rhino-Laryngology 267.3 (2010): 381-384.  Razmpa, Ebrahim, et al. "Correlation of preoperative sinusitis patients' characteristics with final diagnostic findings." Acta Medica Iranica 51.8 (2013).

16. Thank you for your attention