1. Effect of Diabetes Mellitus on Sepsis Induced Multiple Organ Dysfunction Syndrome By Hayes Brown

2. Need Each year 500,000 people develop sepsis, with a survival rate of 29 percent Each year 500,000 people develop sepsis, with a survival rate of 29 percent Millions are spent on patient safety research Millions are spent on patient safety research 250,000 die each year in the United states 250,000 die each year in the United states The main cause of death The main cause of death from sepsis is Multiple from sepsis is Multiple Organ Dysfunction Organ Dysfunction Syndrome (MODS) Syndrome (MODS)

3. Knowledge Base

4. Patients with Diabetes Mellitus (DM) have significantly lower respiratory failure than those without DM Patients with Diabetes Mellitus (DM) have significantly lower respiratory failure than those without DM Greater risk of developing other organ dysfuntions such as Renal failure Greater risk of developing other organ dysfuntions such as Renal failure There are Various theories as to why this may occur There are Various theories as to why this may occur

5. Literature Review Dr. Annette Esper, and Greg Martin found patients with Diabetes Mellietus are less likely to develop respiratory failure during periods of sepsis, but more likely to develop acute renal failure. Dr. Annette Esper, and Greg Martin found patients with Diabetes Mellietus are less likely to develop respiratory failure during periods of sepsis, but more likely to develop acute renal failure. Reasons those with DM are less likely to develop respiratory infection may be DM patients are hospitalized earlier because they are aware more of specific signs of infection, or medications administered to patients with DM (insulin and thiazolidinediones) are known to have anti-inflammatory effects and lower blood glucose level. (Martin) Reasons those with DM are less likely to develop respiratory infection may be DM patients are hospitalized earlier because they are aware more of specific signs of infection, or medications administered to patients with DM (insulin and thiazolidinediones) are known to have anti-inflammatory effects and lower blood glucose level. (Martin)

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