1. 03_37 Mitosis and cytokinesis Slide number: 1 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Early interphase Restriction checkpoint Cleavage furrow Nuclear envelope Chromatin fibers Centrioles Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase A B Aster Microtubules Centromere Spindle fiber Sister chromatids Late prophase Prophase Late interphase MetaphaseAnaphase CD Chromosomes Nuclear envelopes E Telophase and cytokinesis

2. 03_37 Mitosis and cytokinesis Slide number: 2 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Early interphase of daughter cells— a time of normal cell growth and function. Restriction checkpoint Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase A

3. 03_37 Mitosis and cytokinesis Slide number: 3 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Nuclear envelope Chromatin fibers Centrioles Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase Late Interphase Cell has passed the restriction checkpoint and completed DNA replication, as well as replication of centrioles and mitochondria, and synthesis of extra membrane. Restriction checkpoint

4. 03_37 Mitosis and cytokinesis Slide number: 4 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase B Aster Microtubules Prophase Chromosomes condense and become visible. Nuclear envelope and nucleolus disperse. Spindle apparatus forms.

5. 03_37 Mitosis and cytokinesis Slide number: 5 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase B Centromere Spindle fiber Sister chromatids Late prophase

6. 03_37 Mitosis and cytokinesis Slide number: 6 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase C Metaphase Chromosomes align along equator, or metaphase plate of cell.

7. 03_37 Mitosis and cytokinesis Slide number: 7 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase D Anaphase Sister chromatids separate to opposite poles of cell.

8. 03_37 Mitosis and cytokinesis Slide number: 8 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Cleavage furrow Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase Chromosomes Nuclear envelopes E Telophase and cytokinesis Nuclear envelopes begin to reassemble around two daughter nuclei. Chromosomes decondense. Spindle disappears. Division of the cytoplasm into two cells.

9. 03_37 Mitosis and cytokinesis Slide number: 9 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Early interphase of daughter cells— a time of normal cell growth and function. Restriction checkpoint Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase A