1. Ninth Annual Women’s Health Research Conference Sponsored jointly by: Center for Women’s Health Research UNC BIRCWH Program

2. The UNC BIRCWH Program Eugene P. Orringer, MD Professor of Medicine Executive Associate Dean for Faculty Affairs & Faculty Development Principal Investigator, UNC BIRCWH Program

3. UNC BIRCWH Program B uilding I nterdisciplinary R esearch C areers in W omen’s H ealth

4. UNC BIRCWH Program The BIRCWH Program is sponsored by an NIH grant, the primary funding for which comes from the Office of Research on Women’s Health (ORWH)

5. UNC BIRCWH Program The BIRCWH Award employs the K12 Mechanism

6. K12 Award A K12 grant is an institutional award designed to provide protected time to a group of scientists committed to academic research careers. A K12 Award is very much like a training grant, but one that is designed for junior faculty rather than for post- doctoral fellows

7. UNC BIRCWH Program UNC BIRCWH Award was first funded in September, 2000 At its initial funding, this grant brought 5 years of NIH funding with total costs of $500,000 per year We have used the vast majority of these $’s to provide salary support to junior faculty members in exchange for 75% protected research time Our goal has always been to assure that within 2 years each BIRCWH Scholar writes and submits an independent NIH grant (e.g., K23, K08, R01)

8. UNC BIRCWH Program We developed the concept that the UNC BIRCWH Program would have both: BIRCWH Scholars  BIRCWH Scholars BIRCWH Associates  BIRCWH Associates

9. BIRCWH Scholar An individual who is receiving salary support from the BIRCWH grant

10. BIRCWH Associate An individual who had previously received salary support from the BIRCWH grant, but who subsequently went on to compete successfully for his/her own, independent grant support

11. UNC BIRCWH Program This concept (i.e., Scholars and Associates) has enabled us to grow the UNC BIRCWH Program substantially. critical mass By the end of year - 04, our BIRCWH Program had grown to a critical mass of 17 young people (9 MDs, 6 PhDs, 1 PharmD, and 1 MD-PhD), who came to us with remarkably diverse interests and from very different backgrounds, but they all shared a passion & commitment to research in the area of women’s health

12. UNC BIRCWH Program We submitted the competitive renewal for our BIRCWH Program in January, 2005. In the Summary Statement, the reviewers commented: “Overall this application is an outstanding one that has generated success since the inception of the program. It is an outstanding program with a well-dedicated and organized staff and extreme institutional support.” “The grant support and publication record of these BIRCWH Scholars is absolutely remarkable.”

13. UNC BIRCWH Program Indeed, our BIRCWH Program has consistently identified by the NIH as the model for all BIRCWH Programs to emulate. The competitive renewal application that we submitted in early 2005 received an Outstanding Priority Score (126). We received funding for the five year period extending from July 1, 2005 to June 30, 2010.

14. UNC BIRCWH Program Data on our BIRCWH Scholars

15. UNC BIRCWH PROGRAM Total # of Awardees (2000 - Present)23 Women 21 Men 2 Program Graduates (BIRCWH Associates)18 Current BIRCWH Scholars 5 Currently on the Faculty at UNC18 Recruited away from UNC 5 »University of Virginia 1 »San Diego State 1 »Vanderbilt 1 »University of Kentucky 1 »UNC - Greensboro 1

16. UNC BIRCWH PROGRAM BIRCWH Awardees Currently in Academe23 Actively Involved in Women’s Health Research23 BIRCWH Associates (Program Graduates)18 »Active Research Support18 »NIH Grant Recipients16 »American Cancer Society 1 »American Heart Association 1 BIRCWH Scholars (Current awardees) 5 »R03 award from NICHD 1 »K23 from NHLBI (pending) 1 »K23 from NIMH (pending) 1 »Assoc of Women’s Health (Ob & Neonatal Nursing) 1 »None 1

17. UNC BIRCWH PROGRAM NIH Grants Held by BIRCWH Associates »K23 Awards6 »K08 Awards3 »K01 Awards1 »R01 Awards5 »R21 Awards3 »R03 Awards2 »Minority Supplement1 »Misc NIH GrantsZ01, P20, U01, & a Subproject on a P50 Pending NIH Grants »K23 Awards2 »R01 Awards2 »R212

18. UNC BIRCWH PROGRAM Miscellaneous Awards American Cancer Society Pfizer Scholar Award RWJ Foundation AHRQ CDC American Water Works Fdn NSABP Award Doris Duke Foundation ASCO Kimmel Scholar American Heart Association Hemophilia Foundation Industry Awards Boehringer Ingelheim Novo Nordisk Bayer Glaxo SmithKline Gilead Sciences Abbot Labs Marine Polymer Technologies

19. UNC BIRCWH PROGRAM In summary, the BIRCWH Program has been remarkably successful It has enabled us here at UNC to train an entire cohort of women’s health researchers The return on investment for the BIRCWH Award here at UNC has been truly remarkable, as all of our graduates remain in academe, all are actively involved in women’s health research, and each has been able to compete for extramural funding The NIH in general and the Office of Research in Women’s Health in particular deserve a great deal of credit for creating this program