1. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Indiana CTSI 2014 Purdue Retreat Engagement with IU Health Arnett Marietta L. Harrison, PhD Director, Oncological Sciences Center in Discovery Park Professor, Medicinal Chemistry and Molecular Pharmacology

2. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Indiana CTSI 2014 Purdue Retreat Research at Community-based Hospitals The need… Patient populations at tertiary, academic medical centers are skewed Majority of patients are treated locally Less than 3% of patients receiving care at community hospitals and practices participate in clinical trials

3. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Indiana CTSI 2014 Purdue Retreat Research at Community-based Hospitals The barriers…. Physician’s time Physician’s interest Physician’s awareness Lack of hospital administration support Lack of research infrastructure

4. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Indiana CTSI 2014 Purdue Retreat Research at IU Health Arnett Strong support of President and CEO Al Gatmaitan, FACHE Physician Driver Wael Harb, MD (Co-PI on project) Stephen Deutsch, MD (Co-PI on project) Dedicated Study Coordinator Zero to minimal interruption of normal clinical routine The solutions….

5. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Indiana CTSI 2014 Purdue Retreat Research at IU Health Arnett Eliminating Barriers Purdue Community IRB Shared financial support Revise hospital SOPs to accommodate research infrastructure Research Advocate Program Communication, communication, communication!!

6. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Indiana CTSI 2014 Purdue Retreat Research at IU Health Arnett Keys to Success Physicians as equal partners Understanding of clinical operations and constraints on physician’s time Include only physicians who want to participate An appreciation the “voluntary” nature of physician participation