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Published byAlannah McBride Modified over 9 years ago
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Prion
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Similar to Viruses Atypical Agents Small Filterable Need host cells No machinery for energy generation of protein synthesis
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Different from viruses No dectectable virions in infected tissues No detectable virions in purified infectious material If nucleic acid is present, very small Very resistant
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Resistant to or only partially inactivated by 1. Formaldehyde 2. Ethanol 3. Glutaraldehyde 4. Ultraviolet and ionizing irradiation 5. Non-ionic detergents Inactivated by 1. Autoclaving 2. 5%sodium hypochlorite 3. Sodium hydroxide 4. Proteases, urea, other protein denaturants
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Pathogensis Kuru CJD(Creutzfeldt Jakob disease) GSS(Gerstmann Straussler-Scheinker syndrome) FFI(Fetal familial insomnia) Scrapie(sheep and goats) Bovine spongiform encephalopathy Transmissible mink encephalopathy Chronic wasting disease of mule deer
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Simplified model for prion disease.
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How can this model explain the sporadic, acquired or inherited form of the disease?
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Why are there differences in prion diseases?
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