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Prion. Similar to Viruses Atypical Agents  Small  Filterable  Need host cells  No machinery for energy generation of protein synthesis.

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Presentation on theme: "Prion. Similar to Viruses Atypical Agents  Small  Filterable  Need host cells  No machinery for energy generation of protein synthesis."— Presentation transcript:

1 Prion

2 Similar to Viruses Atypical Agents  Small  Filterable  Need host cells  No machinery for energy generation of protein synthesis

3 Different from viruses  No dectectable virions in infected tissues  No detectable virions in purified infectious material  If nucleic acid is present, very small  Very resistant

4  Resistant to or only partially inactivated by 1. Formaldehyde 2. Ethanol 3. Glutaraldehyde 4. Ultraviolet and ionizing irradiation 5. Non-ionic detergents  Inactivated by 1. Autoclaving 2. 5%sodium hypochlorite 3. Sodium hydroxide 4. Proteases, urea, other protein denaturants

5 Pathogensis  Kuru  CJD(Creutzfeldt Jakob disease)  GSS(Gerstmann Straussler-Scheinker syndrome)  FFI(Fetal familial insomnia)  Scrapie(sheep and goats)  Bovine spongiform encephalopathy  Transmissible mink encephalopathy  Chronic wasting disease of mule deer

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7 Simplified model for prion disease.

8 How can this model explain the sporadic, acquired or inherited form of the disease?

9 Why are there differences in prion diseases?

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