1. ASPECTS REGARDING THE ETIOLOGY AND CLINICAL MATTERS OF THE FEBRILE SEIZURES IN CHILDREN First Author: Iulia Laura Gavrila Author: Alina Grama, Adriana Craciun, Diana Lapusneanu, Maria Magdalena Aloje Coordinator: Asist. Univ. Dr. Alina Grama

2. I NTRODUCTION Febrile seizures are the most common seizure disorder in childhood. They are a benign epileptic manifestation of infancy occurring between 6 months and 5 years of age, accompanied by fever and affecting an estimated 2-5 % of children with no neurological history.

3. Purpose: Was the evaluation of febrile seizures on children hospitalized in Pediatric 1 Clinic of Targu Mures. Material and method: A retrospective study was performed on 195 patients diagnosed with Febrile Seizures, between January 2009- December 2012.

4. R ESULTS OBTAINED AFTER GROUPING FS BY SEX AND ENVIRONMENTAL ORIGIN Number

5. Results obtained from the clustering of cases by age Age of patientsMinimAverageMaxim Age group< 6 months 6 months to 5 years > 5 years Percentage in the number of cases5,1 %91,3 %3,6 %

6. T HE NUMBER OF PATIENTS WITH S IMPLE / COMPLEX FS BY AGE Simple FS = generalized seizures, lasting less than 15 minutes, and without recurrence within 24 hours Complex FS = have focal semiology, last more than 15 min and have more than one episode during the same febrile event

7. THE DISTRIBUTION OF CASES IN EACH OF THE 4 YEARS ( INCLUDED IN THIS STUDY )

8. T YPE OF SEIZURE FREQUENCY ACCORDING TO GENDER

9. T YPE OF MANIFESTATIONS

10. F REQUENCY OF DISEASES RELATED TO FEBRILE SEIZURES

11. E TIOLOGY RESULTING FROM THE STUDY

12. B ACTERIAL INFECTION /T YPE OF SEIZURES / SEASONS

13. Results: Family history of seizures and epilepsy Frequency (number) Percent Seizures115,6 No Seizures18494,4 Epilepsy136,7 No Epilepsy18293,3

14. T HE RISK OF RECURRENT FS / AGE <1 YEAR OF THE FIRST FS p=0,01 Value 95% Confidence Interval LowerUpper Odds Ratio for Age of 1st FS< 1 year (da / nu) 3,4341,7096,898 For cohort Recurrent FS = yes 2,3411,4853,690 For cohort Recurent = no,682,523,888 N of Valid Cases 195

15. C ONCLUSIONS As in the literature, this study proves that simple febrile seizures, with tonic-clonic manifestations are most frequently seen especially in male children between 6 months and 5 years old. In addition to this, I have determined that:  The risk of recurrent FS is 3,4 times higher for patients where 1 st F.S. occurred at the age of under 1 year compared to those where it occurred at an age of more than 1 year.  The number of cases is higher in the rural environment  In the 4 study years, the number of cases increased  The bacterial etiology is predominant  Superior airway infections were frequently associated with F.S  Both simple and complex FS appeared more often in spring and winter.

16. B IBLIOGRAPHY http://www.ncbi.nlm.nih.gov/pubmed/24477659# http://www.medscape.com/viewarticle/769023 http://www.ncbi.nlm.nih.gov/pubmed/7594268 Tog ă nel R.: Puericultur ă, Litografia UMF, Târgu-Mure, 2009 Baghiu M.D: Lecţiuni de pediatrie, Târgu-Mureş, 2009, vol. II Baumann RJ. Technical report: treatment of the child with simple febrile seizure. Pediatrics 1999;103:e86.www.pediatrics.org/cgi/content/full/ 103/6/e86 (accessed 19 Junewww.pediatrics.org/cgi/content/full/ Butnariu A., Badiu I., Boros E. : Puericultura şi Pediatrie, Ed. 4, Editura Medicala Universitara Iuliu Hateganu, Cluj Napoca, 2011 Bui T, Delgado C, Simon H – Infant seizures not so infantile: first-time seizures în children under six months of age presenting to the ED. Am J Emerg Med, 2002 Friedman MJ, Sharieff GQ – Seizures în children. Pediatr Clin N Am, 2006 Man C. Sorin, Manulescu V. Mircea : Pediatrie Pediatrica, Editura Risoprint Cluj Napoca, 2006 Popescu V – Convulsiile febrile. Revista Român ă de Pediatrie, 2006, LV

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