1. Cellular Division in Eukaryotic Cells
Mitosis
Catherine Aulicino
Introduction
Metaphase
Interphase
Anaphase
Prophase
Telophase
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Prometaphase
Cytokinesis

2. Introduction Nuclear Division in Eukaryotes
Use this WebQuest to learn about each stage of mitosis and answer the questions.
Nuclear Division in Eukaryotes
Mitosis is the process of nuclear division of eukaryotic cells that produce daughter nuclei that are genetically identical to the parent nucleus.
What are the main functions of mitosis?
Describe the structure and function of the basic cell parts involved in Mitosis.
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Introduction
Interphase
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Cytokinesis

3. Interphase Interphase prepares the cell to undergo cell division.
The G1, S, and G2 phase take place during interphase. What are these terms short for? -
1. G1 Phase: Cellular content, excluding the chromosomes, are duplicated.
2. S Phase: DNA replication and chromatid duplication.
3. G2 Phase: The cell “double checks” the duplicated chromosomes for error, and makes repairs before entering mitosis.
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Introduction
Interphase
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Cytokinesis

4. Prophase
Coil to shape
The nucleolus fades and the chromatin (replicated DNA and proteins) condense into coiled chromosomes and are held together at the centromere.
Identical chromosomes appear as the letter “X”
Nuclear envelope begins to break down.
The mitotic spindle, consisting of microtubules, begins to form and migrate toward the ends of the cell.
What happens during prophase to signal the beginning of prometaphase?
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Introduction
Interphase
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Cytokinesis

5. Prometaphsae
The nuclear evelope breaks down so there is no longer a recognizable nucleus.
The mitotic spindle microtubules elongate from the centrosomes and move toward the the kinetochores.
What are kinetochores? Where are they located?
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Introduction
Interphase
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Cytokinesis

6. Metaphase Align & Attach
Identical chromosomes are prepared for equal distribution between the two daughter cells.
The chromosomes become fully attached to the mitotic spindle.
The chromosomes line-up at the center of the cell, otherwise known as the metaphase plate.
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Introduction
Interphase
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Cytokinesis

7. Anaphase Divide and Drag
Identical chromosomes are pulled apart so the cell can split in half
Centromeres divide, one for each duplicated chromosome
Identical chromosomes separate and are dragged by microtubules to opposite poles of the cell
The cell becomes stretched and elongated
What characteristic shapes appear during chromosome movement?
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Introduction
Interphase
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Cytokinesis

8. Telophase Contract and Expand
The cell begins to restructure in preparation for independence
Chromosomes arrive to the poles and uncoil
Mictrotubules break down
Nuclear envelopes form around chromosomes
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Introduction
Interphase
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Cytokinesis

9. Cytokinesis Separate and Go Your Own Way
The cell finally splits into two independent daughter cells.
In animal cells, cytokinesis involves the formation of a __________ resulting in the pinching of the cell into two.
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Introduction
Interphase
Prophase
Prometaphase
Metaphase
Anaphase
Telophase
Cytokinesis

10. Rubic Each question is worth 5 points. There are 7 questions.
Answers should be taken directly from the websites provided in the webquest.