1. By. Mike Carrier

2. Carl and Gerty Cori were born and lived in Prague Czechoslovakia and they both studied at the German University of Prague Background

3. Glycogen is a polymer of glucose Glycogen is used by many living organisms to store energy Glycogen is found in the liver Converted into lactic acid Prior Knowledge

4. Discovered that the formation of glucose-1- phosphate is linked to glycogen Glucose-1-phosphate is used to transport glucose to muscle cells from the liver When the muscle cells use the glucose, they produce lactic acid The lactic acid is then transported back to the liver and is used to reform glycogen Cori cycle Glucose-1-Phosphate

5. The Coris succeeded in purifying the glucose-1- phosphate The main problem faced when purifying and enzyme, many enzyme-catalyzed reactions are reversible The Coris had to wisely choose the enzyme inhibitors, to isolate the enzymes carrying out the reactions Cori Ester

6. Carl and Gerty Cori’s discovery helped further knowledge in cardohydrate metabolic processes and the discovery of the Cori cycle greatly helped improve the treatment of diabetes later on. In 1947 the Coris won the Nobel prize for psychology or medicine Later on

7. Cori, Carl and Gerty, Robert K. Griffith, http://www.chemistryexplained.com/Co-Di/Cori-Carl-and-Gerty.html Carl Ferdinand Cori and Gerty Theresa Cori, Chemical Heritage Foundation, http://www.chemheritage.org/discover/chemistry-in- history/themes/biomolecules/proteins-and-sugars/cori-and-cori.aspx Gerty Cori, http://en.wikipedia.org/wiki/Gerty_Corihttp://en.wikipedia.org/wiki/Gerty_Cori The Nobel Prize in Physiology or Medicine 1947, Carl Cori, Gerty Cori, Bernardo Houssay, The Official Web Site of the Nobel Prize, http://nobelprize.org/nobel_prizes/medicine/laureates/1947/cori-cf-bio.html Bibliography