1. ISA-TAB-Nano Weekly Meeting May 1, 2012 Use of Informatics to Expedite and Validate the Application of Nanotechnology in Biomedicine

2. Agenda Continued discussion on Material and Manufacturer Lot IDs Continued discussion on versioning and governance Walkthrough of the ISA-TAB-Nano Wiki ISA-TAB-Nano XML Specification

3. Lot IDs Re-Cap from Last Week Add a Manufacturer Lot ID to the Material File Use the Material Source Identifier to record the Material Lot ID Seek guidance from Fred Klaessig regarding adding a Certificate of Analysis/MSDS number Modify the Factor Value [nanoparticle sample] in the Cytotoxicity Study file to Factor Value [material source identifier] to support file linkage

4. Lot ID Reference Updated Material File

5. Material Lot ID Reference Assay File Size by DLS Assay File Cytotoxicity Assay File

6. Material Lot ID Reference Study File Size by DLS Study File Cytotoxicity Study File

7. ISA-TAB-Nano Versioning Current ISA-TAB-Nano Version References ISA-TAB-Nano Wiki – References ISA-TAB-Nano Version 0.6 files and structures ISA-TAB-Nano ASTM Document – References Work Item No.: WK28974. No Version Number referenced. ISA-TAB-Nano Manuscript – No Version Number referenced ISA-TAB-Nano Version Discussion Version 1.0? – Original Nano-TAB submitted to ASTM Version 1.1? – Updated ISA-TAB-Nano version Modification of Material File to reflect a horizontal layout Inclusion of Manufacturer ID (and other related elements) Re-naming of Material Part Name and Material Linkage Name Other? Discuss version control Version control in the ISA-TAB-Nano Wiki Version control in SVN (final file versions only)

8. ISA-TAB-Nano Governance ISA-TAB-Nano Membership ISA-TAB-Nano Standards Development Life Cycle (x Month?) Standards Development Activities (4 Months?) Review feature requests in the ISA-TAB-Nano JIRA Tracker (Month 1) Determine need for standards update and version number (Month 1) Update example files in support of feature requests (Months 1-2) Review/validate example file updates (Month 2) Internal member voting (Month 3) Review comments and finalize updates (Month 3) Update ISA-TAB-Nano work products (Months 3-4) ASTM Ballot, Manuscript, Supporting Information, Wiki Page ASTM Submission (x Months?) Submit updates to ASTM and request ballot submission (Month 4) Support ASTM voting process (Months 4-6?) Review comments and finalize updates (Month 7?) Obtain final ASTM Approval (Month 8?)

9. ISA-TAB-Nano Wiki https://wiki.nci.nih.gov/display/ICR/ISA-TAB-Nano https://wiki.nci.nih.gov/display/ICR/ISA-TAB-Nano Discuss overall structure/content Wiki and relationship to ASTM specification Discuss consistency Representing file example pages Discuss Wiki access Wiki write access

10. ISA-TAB-Nano-ML 11/13/2015

11. Investigation File 11/13/2015

12. Study File 11/13/2015

13. Material File 11/13/2015

14. Assay File 11/13/2015