1. The Cardiovascular System and Its Control

2. The Cardiovascular System: Major Functions Delivers O 2, nutrients Removes CO 2, other waste Transports hormones, other molecules Temperature balance and fluid regulation Acid-base balance Immune function

3. The Cardiovascular System Three major circulatory elements 1. A pump (heart) 2. Channels or tubes (blood vessels) 3. A fluid medium (blood) Heart generates pressure to drive blood through vessels Blood flow must meet metabolic demands

4. The Heart Four chambers –Right and left atria (RA, LA): top, receiving chambers –Right and left ventricles (RV, LV): bottom, pumping chambers Pericardium Pericardial cavity Pericardial fluid

5. Figure 6.1

6. Figure 6.4

7. Intrinsic Control of Heart Activity: Cardiac Conduction System Spontaneous rhythmicity: special heart cells generate and spread electrical signal –Sinoatrial (SA) node –Atrioventricular (AV) node –AV bundle (bundle of His) –Purkinje fibers Electrical signal spreads via gap junctions –Intrinsic heart rate (HR): 100 beats/min –Observed in heart transplant patients (no neural innervation)

8. Intrinsic Control of Heart Activity: Cardiac Conduction System SA node: initiates contraction signal –Pacemaker cells in upper posterior RA wall –Signal spreads from SA node via RA/LA to AV node –Stimulates RA, LA contraction AV node: delays, relays signal to ventricles –In RA wall near center of heart –Delay allows RA, LA to contract before RV, LV –Relays signal to AV bundle after delay

9. Intrinsic Control of Heart Activity: Cardiac Conduction System AV bundle: relays signal to RV, LV –Travels along interventricular septum –Divides into right and left bundle branches –Sends signal toward apex of heart Purkinje fibers: send signal into RV, LV –Terminal branches of right and left bundle branches –Spread throughout entire ventricle wall –Stimulate RV, LV contraction

10. Figure 6.5

11. Figure 3.1

12. Figure 6.8

13. Cardiac Terminology Cardiac cycle Stroke volume Ejection fraction Cardiac output (Q)

14. Cardiac Cycle All mechanical and electrical events that occur during one heartbeat Diastole: relaxation phase –Chambers fill with blood –Twice as long as systole Systole: contraction phase

16. Figure 6.9

17. Stroke Volume, Ejection Fraction Stroke volume (SV): volume of blood pumped in one heartbeat –During systole, most (not all) blood ejected –EDV – ESV = SV –100 mL – 40 mL = 60 mL Ejection fraction (EF): percent of EDV pumped –SV / EDV = EF –60 mL/100 mL = 0.6 = 60% –Clinical index of heart contractile function

18. Cardiac Output (Q) Total volume of blood pumped per minute Q = HR x SV –RHR ~70 beats/min, standing SV ~70 mL/beat –70 beats/min x 70 mL/beat = 4,900 mL/min –Use L/min (4.9 L/min) Resting cardiac output ~4.2 to 5.6 L/min –Average total blood volume ~5 L –Total blood volume circulates once every minute

19. The Vascular System Arteries: carry blood away from heart Arterioles: control blood flow, feed capillaries Capillaries: site of nutrient and waste exchange Venules: collect blood from capillaries Veins: carry blood from venules back to heart

20. Blood Pressure Systolic pressure (SBP) –Highest pressure in artery (during systole) –Top number, ~110 to 120 mmHg Diastolic pressure (DBP) –Lowest pressure in artery (during diastole) –Bottom number, ~70 to 80 mmHg Mean arterial pressure (MAP) –Average pressure over entire cardiac cycle –MAP ≈ 2/3 DPB + 1/3 SBP

21. Figure 7.4

22. General Hemodynamics Blood flow: required by all tissues Pressure: force that drives flow –Provided by heart contraction –Blood flows from region of high pressure (LV, arteries) to region of low pressure (veins, RA) –Pressure gradient = 100 mmHg – 0 mmHg = 100 mmHg Resistance: force that opposes flow –Provided by physical properties of vessels –R = [  L/r 4 ]  radius most important factor

23. Figure 6.11

25. Figure 6.12

26. Distribution of Venous Blood At rest, veins contain 2/3 blood volume –High capacity to hold blood volume –Elastic, balloonlike vessel walls –Serve as blood reservoir Venous reservoir can be liberated, sent back to heart and into arteries –Sympathetic stimulation –Venoconstriction

27. Figure 6.14

28. Return of Blood to the Heart Upright posture makes venous return to heart more difficult Three mechanisms assist venous return –One-way venous valves –Muscle pump –Respiratory pump

29. Figure 6.15

30. Blood Plasma (55-60% of blood volume) –Can decrease by 10% with dehydration in the heat –Can increase by 10% with training, heat acclimation –90% water, 7% protein, 3% nutrients/ions/etc. Formed elements (40-45% of blood volume) –Red blood cells (erythrocytes: 99%) –White blood cells (leukocytes: <1%) –Platelets (<1%) Hematocrit = total percent of volume composed of formed elements