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Clinical outcomes of Epi-LASIK : 1-Year-Long Results of Flap ON/OFF with Mitomycin-C ON/OFF Gil-Joong Yoon (MD/PhD) 1 Seong-Taeck Kim (MD) 2 Jae-Woong.

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Presentation on theme: "Clinical outcomes of Epi-LASIK : 1-Year-Long Results of Flap ON/OFF with Mitomycin-C ON/OFF Gil-Joong Yoon (MD/PhD) 1 Seong-Taeck Kim (MD) 2 Jae-Woong."— Presentation transcript:

1 Clinical outcomes of Epi-LASIK : 1-Year-Long Results of Flap ON/OFF with Mitomycin-C ON/OFF Gil-Joong Yoon (MD/PhD) 1 Seong-Taeck Kim (MD) 2 Jae-Woong Koh (MD/PhD) 2 Happy Eye Clinic, Gwangju, Republic of Korea 1 Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Republic of Korea 2

2 Dr. Koh Dr. KimDr. Yoon

3 Purpose To evaluate and compare of Clinical outcomes of epi-LASIK On-flap vs Off-flap With 0.02% Mitomycin-C (MMC) vs Without MMC Uncorrected visual acuity (UCVA) Spherical equivalent refraction Keratometry Corneal haziness Subjective Pain scores Subjective Satisfaction scores

4 Methods Nonrandomized comparative retrospective study 198 patients (394 eyes) had undergone an epi-LASIK for myopia (-1.5D to -8.0D spherical equivalent) correction Group I : on-flap without MMC (181 eyes) Group II : on-flap with MMC (52 eyes) Group III : off-flap without MMC (93 eyes) Group IV : off-flap with MMC (68 eyes) Outcomes : # POD 1 day / 1 mo / 3 mo / 6 mo / 1 year

5 Baseline Characteristics of eyes for Epi-LASIK surgery *epi-LASIK = epi-laser in-situ keratomileusis † SD = standard deviation §SE = spherical equivalent #D = diopters Mean central corneal thicknesses - No statistical significant difference between the 4 groups (P = 0.131) Mean corneal curvature measured - No statistical significant difference between the 4 groups (P = 0.525)

6 Mean Uncorrected Visual Acuities (A) 1 day (B) 1 month (C) 6 month (D) 12 month 20/25 + 20/20 and more (A) : 10 % (I) / 8 % (II) / 29 % (III) / 27 % (IV) Off-flap (Groups III and IV) >> On-flap (Groups I and II) (P = 0.002) Changes in UCVA for any of the groups : No statistically significance at (B),(C),(D) (P = 0.272, P = 0.514, P = 0.643).

7 Mean Spherical Equivalents Spherical equivalent of myopia : stabilized in all groups No significant regression in all groups In the analysis of correlation between the 4 groups : No significant difference (P = 0.305)

8 Mean Keratometry Mean corneal curvatures : stabilized in all groups In the analysis of correlation between the 4 groups : No significant change (P = 0.128)

9 Corneal Haziness Percentages in every grade of opacity for any of the groups - No statistically significant at all periods (P = 0.533) - No affected by On- or Off-flap methods or by MMC use or non-use (A) 1 day (B) 1 month (C) 6 month (D) 12 month

10 Subjective Pain & Satisfaction scores Numeric Pain Intensity Scale (0 – 10) : On-flap (Groups I & II) >> >> Off-flap (Groups III & IV) (P = 0.010) Grades of patient satisfaction (0-10) : No significant differences between any of the groups (P = 0.248)

11 Conclusions Myopic correction by Epi-LASIK surgery - Stable visual results in 1-year postop. outcomes Off-flap method - Faster visual recovery - Less postoperative pain 0.02% MMC - Less effective than that expected for corneal haziness levels


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