1. Quiz – Write question and answer
Name the 3 types of muscle tissue
Which type of muscle is voluntary?
Name 2 of the 4 functions of muscles
Name the two important filaments found in muscle cells. (Hint: Thick and thin)
T/F A nerve impulse is required to contract a muscle cell

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3. Chapter 6 The Muscular System
Essentials of Human Anatomy & Physiology
Seventh Edition
Elaine N. Marieb
Chapter 6 The Muscular System
Slides 6.18 – 6.31
Lecture Slides in PowerPoint by Jerry L. Cook
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

4. The Sliding Filament Theory of Muscle Contraction
Activation by nerve causes myosin heads (crossbridges) to attach to binding sites on the thin filament
Myosin heads then bind to the next site of the thin filament
Figure 6.7
Slide 6.17a
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5. The Sliding Filament Theory of Muscle Contraction
This continued action causes a sliding of the myosin along the actin
The result is that the muscle is shortened (contracted)
Figure 6.7
Slide 6.17b
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

6. The Sliding Filament Theory
Figure 6.8
Slide 6.18
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

7. Sliding Filament Theory Video Clip

8. Contraction of a Skeletal Muscle
Muscle fiber contraction is “all or none”
Within a skeletal muscle, not all fibers may be stimulated during the same interval
Different combinations of muscle fiber contractions may give differing responses
Graded responses – different degrees of skeletal muscle shortening
Slide 6.19
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9. Types of Graded Responses
Twitch
Single, brief contraction
Not a normal muscle function
Figure 6.9a, b
Slide 6.20a
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10. Types of Graded Responses
Tetanus (summing of contractions)
One contraction is immediately followed by another
The muscle does not completely return to a resting state
The effects are added
Figure 6.9a, b
Slide 6.20b
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

11. Types of Graded Responses
Unfused (incomplete) tetanus
Some relaxation occurs between contractions
The results are summed
Figure 6.9a, b
Figure 6.9c,d
Slide 6.21a
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12. Types of Graded Responses
Fused (complete) tetanus
No evidence of relaxation before the following contractions
The result is a sustained muscle contraction
Figure 6.9a, b
Figure 6.9c,d
Slide 6.21b
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13. Muscle Response to Strong Stimuli
Muscle force depends upon the number of fibers stimulated
More fibers contracting results in greater muscle tension
Muscles can continue to contract unless they run out of energy
Slide 6.22
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

14. Energy for Muscle Contraction
Initially, muscles used stored ATP for energy
Bonds of ATP are broken to release energy
Only 4-6 seconds worth of ATP is stored by muscles
After this initial time, other pathways must be utilized to produce ATP
Slide 6.23
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

15. Energy for Muscle Contraction
Direct phosphorylation
Muscle cells contain creatine phosphate (CP)
CP is a high-energy molecule
After ATP is depleted, ADP is left
CP transfers energy to ADP, to regenerate ATP
CP supplies are exhausted in about 20 seconds
Slide 6.24
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 6.10a

16. Energy for Muscle Contraction
Aerobic Respiration
Series of metabolic pathways that occur in the mitochondria
Glucose is broken down to carbon dioxide and water, releasing energy
This is a slower reaction that requires continuous oxygen
Figure 6.10c
Slide 6.25
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

17. Energy for Muscle Contraction
Anaerobic glycolysis
Reaction that breaks down glucose without oxygen
Glucose is broken down to pyruvic acid to produce some ATP
Pyruvic acid is converted to lactic acid
Slide 6.26a
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 6.10b

18. Energy for Muscle Contraction
Anaerobic glycolysis (continued)
This reaction is not as efficient, but is fast
Huge amounts of glucose are needed
Lactic acid produces muscle fatigue
Slide 6.26b
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 6.10b

19. Muscle Fatigue and Oxygen Debt
When a muscle is fatigued, it is unable to contract
The common reason for muscle fatigue is oxygen debt
Oxygen must be “repaid” to tissue to remove oxygen debt
Oxygen is required to get rid of accumulated lactic acid
Increasing acidity (from lactic acid) and lack of ATP causes the muscle to contract less
Slide 6.27
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

20. Types of Muscle Contractions
Isotonic contractions
Myofilaments are able to slide past each other during contractions
The muscle shortens
Isometric contractions
Tension in the muscles increases
The muscle is unable to shorten
Slide 6.28
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21. Muscle Tone Some fibers are contracted even in a relaxed muscle
Different fibers contract at different times to provide muscle tone
The process of stimulating various fibers is under involuntary control
Slide 6.29
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

22. Muscles and Body Movements
Movement is attained due to a muscle moving an attached bone
Figure 6.12
Slide 6.30a
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

23. Muscles and Body Movements
Muscles are attached to at least two points
Origin – attachment to a moveable bone
Insertion – attachment to an immovable bone
Figure 6.12
Slide 6.30b
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings

24. Effects of Exercise on Muscle
Results of increased muscle use
Increase in muscle size
Increase in muscle strength
Increase in muscle efficiency
Muscle becomes more fatigue resistant
Slide 6.31
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings