1. Today: A little more Strong Inference Why are you connected to polar bears? How do we know that anyone else knows anything?

2. Studying Biology: Start with a question. –For example: How? Why? When? Where? Etc? How do we get answers? –Strong Inference presents one method (article on webpage)

3. What causes Mad Cow Disease (aka BSE)?

4. Brain tissue from cow with BSE. Scrapie in sheep, CJD or Kuru in humans looks similar.

5. How could you test for the infectious agent?

6. Dr. Stanley Prusiner was awarded the Nobel Prize in 1997 for the discovery of prions… infectious proteins.

7. normally folded proteins Prion (abnormally folded protein) Interaction between prion and normal protein causes normal protein to misfold… … which leads to increasing numbers of prions Prion Propogation

8. Two ways to think about the world: atoms molecules organelles cells tissues organs systems organisms environment Reductionism

9. Two ways to think about the world: atoms molecules organelles cells tissues organs systems organisms environment Reductionism holism

10. Two Approaches to Biology holism reductionism

11. To understand complex systems, we must understand simple systems and visa/versa holism reductionism

12. Ecological Interconnections

13. CB 54.24 CO 2 levels in Hawaii and average global temp.

14. Effects of global warming are already visible http://www.nationmaster.c om/graph/env_co2_emi- environment-co2- emissions 1914 2004

15. Polar bears need ice to hunt

16. Sea Ice 1979 2003

17. Without sea ice, polar bears will go extinct

18. Wangari Maathai - Resources and Conflict http://youtube.com/watch?v=dA0qGlnc-30 http://youtube.com/watch?v=dA0qGlnc-30

19. Scientists communicate by publishing their findings in journals…

20. What is in a journal article?

22. Basic info: who, what, where, when

23. The abstract is a summary of the rationale and results.

24. The introduction has background information.

25. What is this?

26. References are how scientists cite other people’s ideas or data. (Castrogiovanni et al., 1998) Castrogiovanni P, Iapichino S, Pacchierotti C, Pieraccini F. 1998. Season of birth in psychiatry: a review. Neuropsychobiology 37:175–181.

27. (Castrogiovanni et al., 1998) Using other’s ideas or data is fine, but not citing where the information came from is plagiarism. Castrogiovanni P, Iapichino S, Pacchierotti C, Pieraccini F. 1998. Season of birth in psychiatry: a review. Neuropsychobiology 37:175–181.

28. SUBJECTS AND METHODS To investigate the influence of birth season on examination marks, we used the (anonymous) examination results from 1995–2001 of undergraduate students at the University of Vienna, together with their dates of birth……. Materials and methods or other synonymous sections detail how the experiments were done.

29. RESULTS The distribution of scores attained by male and female students is associated with their birth season (see data in Table 1)……… The results section details the outcomes of the experiments.

30. RESULTS The distribution of scores attained by male and female students is associated with their birth season (see data in Table 1)……… The results section details the outcomes of the experiments, and refers to the tables and figures in the paper.

31. Figures are graphical representations of data.

32. Sometimes tables are used.

33. DISCUSSION We find that examination scores are related to season of birth in both female and male students, indicating that there could be some biologically significant underlying ontogenetic or early life- history mechanism……… The discussion is where the results are explained and related to other research. (sometimes it is combined with the results)

34. What is in a journal article?

35. Where do we go from here?

36. Evolution: What evolves? -organisms and their genes How does evolution occur? Why does it matter?