1. 1 Clayton Biotechnologies, Inc. One Riverway, Suite 1520 Houston, Texas 77056 713.963.5860 www.claytonbiotech.com Overview of Clayton Biotechnologies, Inc.

2. 2 Clayton Biotechnologies, Inc. is a for-profit company which facilitates the commercialization of medical discoveries made by the Clayton Foundation for Research and its supporting entities. The Clayton Foundation for Research is a nonprofit medical research organization in Houston, Texas established in 1933 by Benjamin Clayton. The mission of the Foundation is two-fold: To transfer the resulting medical research discoveries from the laboratory to the use of the general public by patenting and licensing such technology for development into drugs or other products. To conduct medical research for the purpose of discovering the cause, prevention and cure of diseases for the benefit of mankind

3. 3 We conduct and fund medical research programs at leading universities, hospitals and academic institutions ■ Baylor College of Medicine ■ Baylor College of Medicine Texas Children's Cancer Center ■ North Carolina State University ■ Oregon Health and Science University ■ Salk Institute for Biological Studies ■ The University of Texas at Austin ■ The University of Texas Health Science Center at Houston ■ The University of Texas M.D. Anderson Cancer Center ■ The University of Texas Medical Branch at Galveston ■ University of California, San Diego ■ University of Geneva

4. 4 Some of our start-up companies Depotech, Inc. Qwell Pharmaceuticals, Backed by Arch, Raises a first round $35 million tranche investment for New Cancer, Inflammation Drugs licensed from the Clayton Foundation

5. 5 Some of our Other Licensees

6. 6 Products Brought to the Market Diagnostics Medical devices Therapeutics SCA6 diagnostic tests Complete Ataxia Evaluation

7. 7 FEATURED TECHNOLOGIES Targeted anticancer therapeutics: VEGF-gelonin ; ScFvMel-TNF Drs. Rosenblum & Howell MD Anderson & UCSD RTEF therapy for ocular neovascular disease Dr. Stout OHSU Conditional gene knock-down system using lentiviral-expressed RNAi Dr. Trono University of Geneva Alpha-TEA: stand-alone or combination anticancer therapeutic Drs. Sanders & Kline University of Texas, Austin Prognostic Marker for Breast Cancer Treatment Dr. Keyomarsi, MD Anderson E-clonals: IgG Antibody Discovery, Optimization and Production Dr. Georgiou University of Texas, Austin Pluripotent Stem Cells for Neurotoxicology Testing Dr. Krause University of Geneva Vaccines and Diagnostics for the Ehrlichioses Dr. McBride University of Texas Medical Branch CRFR1 antagnoists to treat tauopathies such as Alzheimer’s Disease Dr. Sawchenko Salk Institute Cripto antagonists for the treatement of cancer Dr. Vale Salk Institute

8. 8 Any questions? Please contact us! Clayton Biotechnologies, Inc. One Riverway, Suite 1520 Houston, Texas 77056 713.963.5860 www.claytonbiotech.com arichardson@claytonbiotech.com