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DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,

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Presentation on theme: "DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand,"— Presentation transcript:

1 DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 Valeria Tarallo, Yoshio Hirano, Bradley D. Gelfand, Sami Dridi, Nagaraj Kerur, Younghee Kim, Won Gil Cho, Hiroki Kaneko, Benjamin J. Fowler, Sasha Bogdanovich, Romulo J.C. Albuquerque, William W. Hauswirth, Vince A. Chiodo, Jennifer F. Kugel, James A. Goodrich, Steven L. Ponicsan, Gautam Chaudhuri, Michael P. Murphy, Joshua L. Dunaief, Balamurali K. Ambati, Yuichiro Ogura, Jae Wook Yoo, Dong-ki Lee, Patrick Provost, David R. Hinton, Gabriel Núñez, Judit Z. Baffi, Mark E. Kleinman, Jayakrishna Ambati Cell Volume 149, Issue 4, Pages 847-859 (May 2012) DOI: 10.1016/j.cell.2012.03.036 Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

2 Figure 1 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

3 Figure 2 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

4 Figure 3 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

5 Figure 4 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

6 Figure 5 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

7 Figure 6 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

8 Figure 7 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

9 Figure S1 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

10 Figure S2 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

11 Figure S3 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

12 Figure S4 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

13 Figure S5 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

14 Figure S6 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

15 Cell 2012 149, 847-859DOI: (10.1016/j.cell.2012.03.036) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

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