1. Slides last updated: March 2015 CRC: EPIDEMIOLOGY

2. 1.Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed on 17/02/2015. Colorectal cancer incidence and mortality 1 Colorectal cancer (CRC) is the third most common cancer in men and second most common in women worldwide, with 1.4 million new cases in 2012 CRC caused 694,000 deaths in 2012, 8.5% of the total. Central and Eastern Europe had the highest mortality rates

3. Rates of CRC incidence and mortality differ worldwide 1 46% of new CRC cases and 52% of deaths by CRC occur in developing countries Highest CRC rates are found in Australia/New Zealand CRC is the 2 nd most common cancer in both men and women in this region Lowest CRC rates are found in Western Africa CRC is the 3 rd most common cancer in men and 4 th most common in women this region Australia/New Zealand Western Europe Southern Europe Northern Europe More developed regions Central and Eastern Europe Northern America Micronesia Eastern Asia World Caribbean South America Western Asia South-Eastern Asia Less developed regions Southern Africa Polynesia Melanesia Central America Northern Africa Eastern Africa South-Central Asia Middle Africa Western Africa 50403020100 2030 Male Female Incidence Mortality 1.Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No.10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010. Available from: http://globocan.iarc.fr, accessed on 15/09/2013. Estimated age-standardized rates (World) per 100,000 4050

4. Five-year survival trend Survival rates for CRC have been steadily improving 1 Survival rates vary depending on stage at diagnosis. The later the stage of diagnosis the lower the survival rates tend to be. 1. SEER. Fast Stats Online. 5 year survival by diagnosis. 1975-2010. All races. All ages. Male and Female. Available online from seer.cancer.gov/faststats/selections.php, last accessed on 17/03/2015. Colorectal cancer Lung cancer

5. Adenocarcinoma (>95%) CRC (100%) Adenocarcinomas make up more than 95% of CRC 1 Less common types of CRC: Carcinoid tumours Gastrointestinal stromal tumours (GISTs) Lymphomas Sarcomas Adenocarcinomas start in gland cells that make mucus to lubricate the inside of the colon and rectum 1.American Cancer Society. Colorectal Cancer Detailed Guide, 2014. Available online from http://www.cancer.org/acs/groups/cid/documents/webcontent/003096-pdf.pdf, last accessed on 17/03/2015.