1. Life Sciences Trend Analysis 2013 UNITED KINDGOM

2. About Us The following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology, Pharmaceutical and Medical Device industries. www.biotechgate.com www.biotechgate.com The UK Biotech Database is a part of the global Biotechgate and is brought to you in partnership with University of Oxford, Oxfordshire economic partnership and One Nucleus; a membership organisation for international life science and healthcare companies. ww.ukbiotech.comww.ukbiotech.com Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.comwww.venturevaluation.com

3. Status of the Sector 2012 Statistics UK 2013 Statistics 614Total Biotech Companies664 168Biotech - Therapeutics192 394Biotech - R&D Services413 52Biotech - Other59 91%Percentage of SME's82% 7%Percentage of Publicly Owned Companies6% USD 283 M (2011) Financing/Capital Raised USD 527 M (2012) 302Licensing Opportunities361

4. Key Activities of Biotechnology Companies Historical Data Subsector20132012 Contract Research & Manufacturing 18%17% Diagnostics and Analytical Services 21%20% Bioinformatics & Bioelectronics4% Drug Delivery4%5% Other Services and Suppliers25%26% Therapeutics16% Other12%

5. Company Foundation Timeline

6. Company Ownership Historical Data Subsector20132012 Private/ Independent 75%74% Public6%7% Subsidiary19%

7. Sources of Company Foundations Historical Data Company Foundation20132012 Independent foundation41%47% Spin-off from company2%3% Spin-off from public institution / NPO2%3% Spin-off from university11%16% Subsidiary18%22% Other3%6%

8. Number of Employees Historical Data No. of Employees20132012 1-1028% 11-5038%33% 51-20016%30% Greater than 20018%6%

9. Products in the Pipeline

10. Financing Rounds in the UK & 3 Major Financing Rounds Financing for 2012/2013 Private Biotech Companies Major Financings in 2012/2013SectorUSD M Gazasia LtdBiotech – Other150 Circassia Limited Biotech – Therapeutics & Diagnostics 76 Cell Medica Ltd Biotech – Therapeutics & Diagnostics 42

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12. Terms of Use The “UK Life Sciences Trend Analysis” is based on data entered in the Biotechgate Database available at www.biotechgate.com. The statistics and graphs in this presentation are based on figures and information entered in this database and we do not guarantee any accuracy hereof. The use of the figures and graphs provided in this report is free of charge for any presentations as long as www.biotechgate.com is clearly cited as the source. For all other uses please contact us for terms and conditions. Biotechgate c/o Venture Valuation VV AG Kasernenstrasse 11+41 (43) 321 86 60 8004 Zurichinfo@venturevaluation.com Switzerlandwww.venturevaluation.com