1. Phypode kickoff meeting Zeljko Dujic, MD, PhD Department of Physiology, University of Split School of Medicine, Croatia Brest, France, January 2011

2. Current research topics SCUBA diving (trimix and air) a)Impact on cardiovascular system b)Alterations in respiratory function c)Vascular gas bubbles assessment and reduction d)Appearance of gas bubbles in systemic circulation

3. Diving and cardiac function Cardiovascular parameters here Marinovic et al., Med Sci Sports Exerc. 2010 Jun;42(6):1054-61. Multiday trimix diving

4. Obad et al., J Physiol. 2007;578(Pt 3):859-70. Antioxidants administration After air dive Diving and endothelial function After trimix dives Obad et al., Clin Physiol Funct Imaging (In press).

5. Lung water accumulation  Assessed as ECHO lung comets  Water in lung insterstituim  Normally low number in healthy individuals  Assessed after multiday trimix dives  Acutely increased number of LC after each dive  Paralleled with increased pulmonary artery pressure  Remain elevated >24h after multiday consecutive diving

6. Echocardiographic imaging Logicbook GE Vivid 3 GE Vivid q Ultrasound Doppler  Application of new techniques in assessment of VGE dynamics and distribution

7. Procedures for reducing gas bubble load From Dujic et al., J Physiol. 2004;555(Pt 3):637-42. From Dujic et al., Med Sci Sports Exerc. 2006; 38(8):1432-5. Exercise training 24h before dive Nitroglycerine administration 30 min predive

8. Ongoing studies  The significance of bubbles arterialization for development of adverse clinical outcomes  Alterations of physiological parameters during diving (underwater measurements)  Diving fitness and common pathology (e.g. hypertensive and cardiac patients)  Genetic base for susceptibility of decompression sickness

9. Thank you www.mefst.hr/physiology