1. Turn in your vocabulary project… Then set up the next two pages in your journal. Page: 32 Title: DNA Worksheet Date: 10-9-14 (NOT Cornell notes…tape your worksheet to this page) Page: 33 Title: DNA Replication Date: 10-16-14 Essential Question: How can I describe DNA replication? Set up for Cornell Notes!

3. Replication: making an identical copy Before a cell divides, it must copy its DNA.

4. Why make a copy? cells copy their DNA so that every new cell will have the exact same DNA in its nucleus *DNA never, ever, ever, ever, EVER leaves the nucleus!*

5. replication begins at a single point on the double helix proceeds in two directions (along both strands) until complete ALWAYS occurs in the nucleus

6. Why does DNA replication always happen in the nucleus?

7. enzymes are used to add new base pairs to both strands replication happens in a 5’  3’ direction end result = two identical DNA molecules

8. enzymes used include: −helicase = unzips the double helix −DNA polymerase = creates the new DNA polymer

9. Why is the unzipping enzyme called “helicase”? (remember, enzymes are named after their job!)

10. each half of the DNA double helix has everything it needs to recreate the other half the two strands are complementary complementary = something that completes or enhances something else

11. If you only have one strand of a DNA molecule, how can you fill in the other half?

12. Semi-conservative: each new molecule is made of one original and one new (complementary) strand

13. The complementary strand for AGGCTAAGTCGGTA is TCCGATTCAGCCAT…

14. Your turn… Write the complementary strand for the following sequence: CGGAATTCG GCCTTAAGC

15. How does the structure of DNA make it easy to replicate?

16. DNA Replication Foldable 1.Fold the edges of your paper toward the BACK along the dotted lines. 2.Now fold the two sides in to meet in the middle (also marked with a dotted line). 3.Using the given ORIGINAL strand, complete the complementary strand. 4.Open your edges. Now “replicate” the DNA by filling in the two new strands. 5.Put your name on your paper and turn it in! I will keep them until next week, when we will add another step.