1. ENLIGHT- PARTNER Meeting, 18 -19 June 2009, IFIC- Valencia Manjit DOSANJH ENLIGHT Coordinator & CERN

2. History ENLIGHT was established in 2002 Composed of: HIT, ETOILE, CNAO, CERN, ESTRO, GSI, Karolinska, MedAustron, TERA, Czech Rep, Spain Funded as a network by the EC, 2002 - 2005 Main achievements: Creation of a European Hadrontherapy Community Common multidisciplinary platform with a common vision Served as a vehicle for education and dissemination At the end of the funding: ENLIGHT community showed clear desire for continuing and helping new initiatives…. 2 Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009

3. Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 ENLIGHT provides a multidisciplinary European collaboration amongst partners interested in hadrontherapy ENLIGHT acts as a platform for defining research needs Developing projects and securing funding and collaboration ENLIGHT is a useful resource for other communities interested in hadrontherapy ENLIGHT++ in 2009 3

4. What are the needs of the community? Trained researchers in this new multidisciplinary field Access to the facilities and beam time for research Imaging, TPS, organ-motion ……. Information sharing and networking Improving present technologies/facilities Funding …………………………………. Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 4

5. THE PARTNER PROJECT PAR ticle T raining N etwork for E uropean R adiotherapy TRAINING Clinical Biological Technical (Instrumentation) Young Researchers  Future Leaders in Ion Therapy RESEARCH Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 5

6. Ten Institutes: CERN (Project Coordinator), CNAO, GSI, UKL-HD (HIT), KI, UNIS, TERA, MEDAUSTRON, ETOILE, IFIC Two leading companies in particle therapy: IBA, SIEMENS Multi-disciplinary research: Radiobiology, Dosimetry, Treatment Planning, Novel gantry design, Simulations, Clinical studies Mobility of researchers and a common network THE PARTNER PROJECT Joint Research & Training Programme Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 6

7. 1.Clinical Studies: 1 ER, CNAO; 1 ER, HIT 2 ER 2.Epidemiology & Patient Selection: 1 ER, CNAO; 1 ER, HIT 2 ER 3. Radiobiology: 2 ESR, GSI; 2 ESR, KI ; 1 ESR, Surrey 5 ESR 4. Treatment Planning: 1 ESR, Surrey; 2 ESR, IBA; 1 ESR, MedAustron 4 ESR 5.Simulation and Dosimetry – GEANT/FLUKA: 1 ESR, CERN; 1 ER, HIT; 1 ESR, Siemens 2ESR + 1ER 6.Image Guided Hadron Therapy: 1 ESR, CNAO; 1 ESR, Siemens 2 ESR 7.PET prototype, In-situ Monitoring; 1 ESR, KI; 1 ESR, TERA 2 ESR 8. Novel Gantry design: 1 ESR, CNAO 1 ESR 9.ICT and prototype GRID: 3 ESR, CERN 3 ESR 10.Novel accelerator study: 1 ESR, TERA 1 ESR TOTAL20 ESR + 5 ER PARTNER KICK-OFF MEETING, 16-17 October, 2008

8. Key details for PARTNER Contribution from European Commission: 5.6 M€ 25 young researchers PARTNER wide training in all collaborating institutes 20 technical training workshops in hadron therapy open to all young researchers: www.cern.ch/partner 8 Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009

9. EU: Infrastructure FP7 ULICE Union of Light Ions Centres in Europe Three types of activities are in the project Trans-national Access (TA) Joint Research Activities (JRA) Networking Activities (NA) 9 Courtesy of Prof. Roberto Orecchia, CNAO Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009

10. No.Organisation (full name)Short NameCountry 1Centro Nazionale di Adroterapia OncologicaCNAOItaly 2Medical University of ViennaMUVAustria 3University Hospital of HeidelbergUKL-HDGermany 4CERN Switzerland 5MedAustronMEDAAustria 6EtoileETOILEFrance 7RKA MarburgUKMGermany 8Gesellschaft für SchwerionenforschungGSIGermany 9Karolinska InstitituteKARSweden 10Oxford UniversityUOXFUK 11Technical University of DresdenTUDGermany 12Siemens AG - MED PT PLM PSAGGermany 13European Society for Therapeutic Radiology and OncologyESTROBelgium 14Université Catholique de LouvainUCLBelgium 15Medical University AarhusAARDenmark 16Radboud Medical University NijmegenUMCNNetherlands 17Ion Beam Applications SAIBABelgium 18Istituto Nazionale di Fisica NucleareINFNItaly 19Maria Sk ł odowska Curie Memorial Institute KrakowCOOKPoland 20ArchadeARCFrance 10 ULICE Union of Light Ion Centres in Europe Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009

11. ULICE Union of Light Ion Centres in Europe ULICE is a multidisciplinary initiative that involves all the major players in Europe in the field of hadrontherapy, integrating clinical, physical, biological, and technological knowledge ULICE structure : -General coordination: Roberto Orecchia, CNAO -Trans-national access: Juergen Debus, HIT -Joint research activities: Richard Poetter, Vienna University -Networking activities: Manjit Dosanjh, CERN Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 11

12. ULICE The development of new instruments, the transnational European access to the existing facilities and the different communities (researchers, clinicians, patients) requires a broad network structure. The overall aims of ULICE are: enable the full exploitation of all available resources access to information improvement of the existing and upcoming facilities Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 12

13. provide beam-time for external researchers through clinical trial programmes aimed at improving different technical aspects of the facilities. provide beam-time through ‘ open requests ’ from external researchers for radiobiological and physics experiments Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 13 ULICE: Transnational access

14. Develop methods to match the volume treated by active scanning particle beams to the target volume Develop novel adaptive treatment planning identify tumours that need the superior physical selectivity provided by ion beams Develop/investigate a new carbon ion gantry design Develop computer assisted patient selection program based on epidemiologocal and other data Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 14 ULICE: Joint Research Activities

15. European project: ULICE Status of the project: Approved (8.4 M Euro) Negotiation closed Grant agreement to be signed Project to start in 2009 Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 15

16. ENVISION European Novel imaging systems for in vivo monitoring and quality control during tumour ion beam therapy 16 Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009

17. ENVISION Coordinator: Manjit Dosanjh Approved for 6M Euros Development of new solutions for ▪ real-time, in-vivo monitoring ▪ quantitative imaging ▪ precise dose quantification ▪ feedback to treatment planning ▪ real-time feedback for moving organs 17 Courtesy of Prof. Amaldi Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009

18. Manjit Dosanjh, IFIMED Symposium,10 June 2009 Valencia 18 F. Sauli (TERA) and M. Rafecas (CSIC) W. Enghardt (Oncoray) and D. Dauvergne (CNRS/ETOILE) K. Parodi (UKL-HD) and G. Baroni (Polimi/TERA) D. Georg (MUW) and B. Jones (UOXF) G. Battistoni (INFN) and I. Buvat (CNRS) 18 Courtesy of Prof. Amaldi

19. ENVISION will complement ULICE project in that it focuses on investigating and increasing the potentials and quality of time-resolved in beam PET imaging for real-time in-vivo dosimetry of moving targets. Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 19 ENVISION

20. HadroNET (Pawel OLKO) 20 Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009

21. Future Perspectives Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 21

22. FP7-PEOPLE-2010-ITN (Initial Training Network) Call date: Sept 8 th 2009 Submission date: Dec. 22nd 2009 Could form a training platform linked to ENVISION Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 22 Training Network

23. No. 69 - Hadron therapy facilities. A follow-up project of ULICE will be strongly encouraged for the third Call (Jan 2012). Justification: An FP7 Integrating Activity will be funded until early 2013 (“ULICE” project). Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 23 Integrating Activity projects until the end of FP7 (Draft)

24. Composition of ENLIGHT steering committee…………… 24 Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009

25. ENLIGHT Steering Committee (I) Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 25

26. ENLIGHT Steering Committee (II) Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 Manjit Dosanjh, ENLIGHT Meeting, IFIC- Valencia, 19 June 2009 26