1. Author:ELENA DANCIU Coordinators:Assistant Professor Dr.Marius Mate i Prof.Dr. Horatiu Suciu Prof.Dr. Horatiu Suciu

2. Patent Ductus Arteriosus Patent Ductus Arteriosus persistence communication Definition : PDA represent postpartum persistence of the embryological communication between distal area of Aortic Isthmus and left Pulmonary Artery. Simptoms:  vary with the size of the defect and whether the baby is full-term or premature.  fatigue  fatigue while eating  malnutrition  growth deficiency  tachypnea  tachycardia  Sweating  Sweating during crying or eating Complications : congestive heart failure bronchopulmonary dysplasia necrotizing enterocolitis intracranial hemorrhage renal insuficiency

3. RISK FACTORS/TREATMENT

5. OBJECTIVES T he aim of my study is to evaluate by a descriptive survey the PDA records of Cardiovascular Diseases and Transplant Institute-Tg.Mures and to state some conclusions related to clinical and therapeutic approach of this pathology. Points of interest:  Mean age of the patients at the surgical intervention time  Gender distribution  Prevalence association of PDA with other Congenital Heart Defects  Prevalence association of PDA with other Congenital Heart Defects depending on gender  Mean weight /height at the time of surgery time  Association between Down Sindrom and PDA+other malformations;  The frequency of different Congenital Heart Defects that require maintaining Patency of the ductus. T he aim of my study is to evaluate by a descriptive survey the PDA records of Cardiovascular Diseases and Transplant Institute-Tg.Mures and to state some conclusions related to clinical and therapeutic approach of this pathology. Points of interest:  Mean age of the patients at the surgical intervention time  Gender distribution  Prevalence association of PDA with other Congenital Heart Defects  Prevalence association of PDA with other Congenital Heart Defects depending on gender  Mean weight /height at the time of surgery time  Association between Down Sindrom and PDA+other malformations;  The frequency of different Congenital Heart Defects that require maintaining Patency of the ductus.

6. Material and Method Material and Method  Type of study: descriptive and analytical study, retrospective  Location : Cardiovascular Disease and Transplant Institute in Targu Mures  343 medical records : 188females~55% and 155 males~45%  Time period of study: from January 5th 2011 to December 23th 2014.  Data collected: age, sex, weight, length, type of CHD associated with PDA, type of therapeutic intervention;  Type of study: descriptive and analytical study, retrospective  Location : Cardiovascular Disease and Transplant Institute in Targu Mures  343 medical records : 188females~55% and 155 males~45%  Time period of study: from January 5th 2011 to December 23th 2014.  Data collected: age, sex, weight, length, type of CHD associated with PDA, type of therapeutic intervention; The datas were analyzed by SPSS software and Chi-Square test was used to compare variables between groups.

7. RESULTS Mean age of the patients at the time of surgery

8. WEIGHT(kg)HEIGHT(cm) Number of values343 Minimum1,10037,00 Median5,30063,00 Maximum53,00161,0 Mean8,44871,73 Std. Deviation7,78023,74 The Mean Weight and Height at the time of surgery

9. Prevalence and association of PDA with other Congenital Heart Defects

10. ISOLATED PDA/GENDER ISOLATED PDA/GENDER p=0,000

11. Fallot Tetralogy/Gender p=0,015

13. AORTIC COARCTATION/GENDER p=0,007 p=0,007

16. Fallot Tetralogy/Ductal dependent Fallot Tetralogy/Ductal dependent circulation circulation p=0,028 p=0,028

17. Aortic Coarctation/Ductus Aortic Coarctation/Ductus dependent circulation p=0,000 dependent circulation p=0,000 RESULTS

18. Pulmonary Valve/Branch Atresia//Ductus dependent circulation Pulmonary Valve/Branch Atresia//Ductus dependent circulation p=0,000 p=0,000 RESULTS

19. DISCUSSION

20. CONCLUSIONS 1.Gender equality regarding the incidence of PDA; 2. The association between PDA+FT,PDA+Aortic Coarctation and PDA+TGA have a higher frequency in males than in females 3. Isolated PDA is more frequent in females than in male; 4. The most frequent CHD associated with PDA are :PDA+ASD,PDA+VSD,PDA+TGAand PDA+AoCo.; 5.Some of the CHD that are less associated with PDA are:Hypoplasia of Aortic Arch,Tricuspid Insufficiency,Tricuspid/Mitral Stenosis; 6.Down Sindrome has a statistical singnificance for association with PDA+Pulmonary Hipertension and PDA+ Atrioventricular comun ductus; 7.The association between Ductal Dependent Circulation and: Fallot Tetralogy,Aortic Coarctation and Pulmonary Valve/Branch Atresia has an important statistical significance 1.Gender equality regarding the incidence of PDA; 2. The association between PDA+FT,PDA+Aortic Coarctation and PDA+TGA have a higher frequency in males than in females 3. Isolated PDA is more frequent in females than in male; 4. The most frequent CHD associated with PDA are :PDA+ASD,PDA+VSD,PDA+TGAand PDA+AoCo.; 5.Some of the CHD that are less associated with PDA are:Hypoplasia of Aortic Arch,Tricuspid Insufficiency,Tricuspid/Mitral Stenosis; 6.Down Sindrome has a statistical singnificance for association with PDA+Pulmonary Hipertension and PDA+ Atrioventricular comun ductus; 7.The association between Ductal Dependent Circulation and: Fallot Tetralogy,Aortic Coarctation and Pulmonary Valve/Branch Atresia has an important statistical significance

21. Yuk Law, Jeff Smallhorn and Ian Adatia: Echocardiographic delineation of anomalous origin of the right subclavian artery from the right pulmonary artery, Cardiology in the Young / Volume 7 / Issue 03 / July 1997, pp 328 - 330 Echocardiographic delineation of anomalous origin of the right subclavian artery from the right pulmonary arteryCardiology in the YoungVolume 7Issue 03 Shanmugasundaram Sivakumar, Lleona Lee, Angela Tillett, Francis Wells, Jon Dunning and A Wilf Kelsall: Outcome of ligation of the persistently patent arterial duct in neonates as performed by an outreach surgical team, Cardiology in the Young /Volume 17 / Issue 05 / October 2007, pp 541 - 544 Outcome of ligation of the persistently patent arterial duct in neonates as performed by an outreach surgical teamCardiology in the YoungVolume 17Issue 05 Austine K. Siomos, Max B. Mitchell and Brian M. Fonseca: Successful surgical repair of a massive window duct in a 1-month old with aniridia and pulmonary interstitial glycogenosis, Cardiology in the Young / Volume 25 / Issue 03 / March 2015, pp 594 - 596 Successful surgical repair of a massive window duct in a 1-month old with aniridia and pulmonary interstitial glycogenosisCardiology in the YoungVolume 25Issue 03 Michele D’Alto, Giuseppe Santoro, Maria T. Palladino, Francesco Parisi and Maria G. Russo: Patent ductus arteriosus stenting for palliation of severe pulmonary arterial hypertension in childhood, Cardiology in the Young / Volume 25 / Issue 02 / February 2015, pp 350 - 354 Patent ductus arteriosus stenting for palliation of severe pulmonary arterial hypertension in childhoodCardiology in the YoungVolume 25Issue 02 Ravikumar Parikh, Robert J. S. Negrine, Ashish Chikermane, Shree Vishna Rasiah and Andrew K. Ewer: Assessment of myocardial function in preterm infants with patent ductus arteriosus using tissue Doppler imaging, Cardiology in the Young /Volume 25 / Issue 01 Assessment of myocardial function in preterm infants with patent ductus arteriosus using tissue Doppler imagingCardiology in the YoungVolume 25Issue 01

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