1. Biology 211 Anatomy & Physiology I Dr. Thompson Tissues Of The Human Body

2. Recall: SYSTEMS are composed of one or more organs, all serving a common function ORGANS are composed of one or more types of tissues, all serving a common function TISSUES are composed of one or more types of cells and their products, all serving a common function The study of structure at the level of tissues is called histology.

3. All tissues: - Cells - Extracellular Matrix Ground Substance Fibers

4. Epithelium lines internal and external surfaces, including hollow organs. Forms glands. Connective Tissue provides support and fills spaces Muscle Tissue produces force and movement Nervous Tissue carries and integrates electrical information Each of these can have one or more subtypes With only a few, rare exceptions, all organs of the human body are composed of four types of tissue:

5. Epithelium - Covers body surfaces (e.g. skin, cornea) - Lines body cavities (e.g. peritoneal & pericardial cavities - Lines insides of hollow organs (e.g. stomach, heart, lung, aorta, oviduct) - Forms glands (e.g. sweat glands, pancreas, salivary glands)

6. Characteristics of Epithelium - Highly cellular, with very little extracellular matrix - Cells form close contacts with each other - Avascular - High capacity for regeneration Functional characteristics of epithelia depend on the cells, rather than the extracellular matrix which is unspecialized

7. Epithelium always supported by connective tissue and separated from it by a basement membrane. Depends on connective tissue for vessels, nerves, etc. Epithelium Basement membrane Connective tissue Mucous Membrane or Serous Membrane

8. Epithelium Different types for different functions. Classified according to: a) Number of layers of cells b) Shape of cells in the top layer Single layer = "simple" Two or more layers = "stratified" Actually one layer but looks like more = "pseudostratified" Flat = "squamous" Cube-shaped = "cuboidal" Taller than wide = "columnar" Change shape from squamous to cuboidal = "transitional"

10. Epithelium Number of layers Shape of surface cells Squamous Simple Cuboidal Stratified Columnar Pseudostratified Transitional

11. Simple Squamous Epithelium Simple Cuboidal Epithelium Simple Columnar Epithelium Pseudostratified Columnar Epithelium

12. Stratified Squamous EpitheliumStratified Cuboidal Epithelium (Stratified) Transitional EpitheliumStratified Columnar Epithelium

13. Epithelium also forms all glands in the body Glands classified by a) Whether or not they have ducts b) Their method of secretion Yes = Exocrine; Duct carries product to surface No = Endocrine; Product secreted into surrounding extracellular matrix, picked up by blood vessels Merocrine: Product released from undamaged cells Apocrine: Top part of cell lost during secretion Holocrine: Entire cell lost during secretion

14. Exocrine glands also classified by c) Shape, and whether or not either the duct and/or the secretory part branches

15. Connective Tissue - Lots of extracellular matrix; Relatively few cells - Cells usually do not communicate with each other - Highly vascular - Different types of CT all arise from embryonic mesenchyme Functional characteristics of connective tissues depend primarily on the extracellular matrix, which is often highly specialized, and not on the cells.

16. Connective Tissues Common cellsFibers Fibroblasts / FibrocytesCollagen AdipocytesElastic Mast cellsReticular Plasma cells Macrophages Lymphocytes (many others) How those cells and fibers are arranged determines the specific type of connective tissue

17. Connective Tissues Ordinary connective tissues Specialized connective tissues Loose (areolar) connective tissue Adipose connective tissue Reticular connective tissue Elastic connective tissue Dense regular connective tissue Dense irregular connective tissue Blood Bone Cartilage

18. Loose / Areolar Connective Tissue Adipose Connective Tissue Reticular Connective Tissue

19. Dense Regular Connective Tissue Dense Irregular Connective Tissue

20. Specialized Connective Tissues: Cartilage Hyaline Cartilage Elastic Cartilage Fibrous Cartilage More detail on cartilages and their cells when we discuss the skeletal system

21. Specialized Connective Tissues: Bone Blood More detail on these tissues and their cells when we discuss the skeletal and circulatory systems

22. Muscle Tissue: Skeletal Muscle Cardiac Muscle Smooth Muscle Striated Nonstriated Involuntary Voluntary

23. Very long Unbranched Shorter Branched Short Unbranched Spindle-shaped Hundreds per cell Peripheral One or two per cell Central One per cell Central Yes No Skeletal Cardiac Smooth Muscle Muscle Muscle Myocytes Nuclei Striations

24. Skeletal Cardiac Smooth More detail on muscle tissues and their cells when we discuss the muscular system

25. Nervous Tissue: (no subtypes) 1) Neurons (Excitable cells) Carry electrical signals from one place to another 2) Supporting Cells Nonexcitable Support & nourish neurons Glia in CNS Satellite cells Schwann cells More detail on nervous tissue and its cells when we discuss the nervous system