1. ADVANCING IN SCIENTIFIC CONTROVERSY BIPOLAR PATIENTS WITH/WITHOUT PERSONALITY DISORDER: DO SIGNIFICANT DIFFERENCES EXIST? Sofía M. Carazo Diego Barral Mariana Castrillo Nuria Cruz Ángel Fernández Juan D. Molina M. Teresa Rosique M Victoria Sánchez

2. OBJECTIVES To determine whether there are significant differences in: socio-epidemiological variables, symptom severity and hospitalization resources between bipolar patients with and without personality disorder.

3. METHODS  Observational study  Authorized by the Research Ethics Committee  Chart review of all bipolar patients admitted between 2000 and 2010  Aged > 18 years at last hospitalization on mania  We compared socio-demographic, clinical and hospitalization resources data for patients with/without comorbid personality disorder (ICD9 criteria) diagnosis

5. Personality Disorder (Last Manic Episode) P Value YESNOTotal DESCRIPTIVE Count (%) or Mean ± SD Gender 0.343 Male17 (52)80 (42)97 Female16 (48)112 (58)128 Total33192225 Age 42.45 ± 12.8646.35 ± 15.09 2250.164 Total33192 Marital Status 0.832 single/divorced/widow/sep19 (68)110 (64)129 married/with partner9 (32)62 (36)71 Total28172200 Number of Children 0.81 ± 1.070.95 ± 1.16 Total311792100.524 Education 0.415 Non complete college12 (63)61 (73)73 Complete college7 (37)23 (27)30 Total1984103 Lives With 1.000 Alone or "non family"3 (12)20 (16)23 partner or family21 (88)104 (84)125 Total24124148 Laboral Status Inactive/Unknown24 (73)137 (71)161 Active9 (27)55 (29)64 Total331922250.527

6. No clinical differences in manic episode except for:  Trend to a higher percentage of previous suicide attempts in bipolar patients with personality disorder (27% versus 15%, p=0.078).  Personality disorder patients had more previous suicide attempts (0.86 versus 0.29, p=0.003).  No differences in CGI were present at admission, neither at discharge.

7. Personality Disorder (Last Manic Episode) P Value YESNOTotal RESOURCE VARIABLES Count (%) or Mean ± SD Length of Hospital Stay (days) 26.52 ± 19.1029.04 ± 22.60 2250.545 Total33192 Total Days in hospital over 10 years (Our Area) 73.57 ± 69.4565.16 ± 95.25 570.762 Total1443 Number of episodes in 10 years (Our Area) 4.23 ± 3.112.78 ± 2.46 590.083 Total1346 Number of admissions on manic episode in 10 years 2.42 ± 2.131.59 ± 1.51 Total1442560.115 Number of admissions on depressive episode in 10 years 0.78 ± 1.920.19 ± 0.45 Total1442560.065 Number of admissions on mixed episode in 10 years 0.28 ± 0.820.28 ± 0.50 Total144256 1.000

8. CONCLUSIONS  Comorbid personality disorder in our sample was low and has not been associated to socio-epidemiological differences regarding bipolar patients.  Our findings show an association between comorbidity with personality disorder and previous suicide attempts as well as with more depressive and manic episodes of bipolar illness and an increased use of hospital resources over a decade.  BIBLIOGRAPHY: Apfelbaum S et al (2013); Nieto K et al (2009); Zimmerman M et al (2010);