1. Understanding Cancer and Related Topics Understanding Nanodevices Developed by: Jennifer Michalowski, M.S. Donna Kerrigan, M.S. Jeanne Kelly Brian Hollen Explains nanotechnology and its potential to improve cancer detection, diagnosis, and treatment. Illustrates several nanotechnology tools in development, including nanopores, quantum dots, and dendrimers. These PowerPoint slides are not locked files. You can mix and match slides from different tutorials as you prepare your own lectures. In the Notes section, you will find explanations of the graphics. The art in this tutorial is copyrighted and may not be reused for commercial gain. Please do not remove the NCI logo or the copyright mark from any slide. These tutorials may be copied only if they are distributed free of charge for educational purposes.

2. What Is NanoBiotechnology? Nanodevices Nanopores Dendrimers Nanotubes Quantum dots Nanoshells Tennis ballA periodWhite blood cell Water molecule

3. Designing Nanodevices for Use in the Body Too BigToo Small

4. Manufacturing Nanodevices Scattered X-rays Atoms in crystal Detector NanodevicesCrystalWhite blood cell CrystalX-ray beam

5. Nanodevices Are Small Enough to Enter Cells Cell White blood cell Water molecule Nanodevices

6. Nanodevices Can Improve Cancer Detection and Diagnosis ImagingNanoBiotechnologyPhysical Exam, Symptoms

7. Nanodevices Can Improve Sensitivity and determine which cells are cancerous or precancerous. Precancerous cells Normal cells Nanodevices could potentially enter cells Precancerous cells Normal cells

8. Nanodevices Can Preserve Patients’ Samples Cells from patient Cells preserved Active state preserved Cells altered Active state lost Additional tests Cells from patient Nanotechnology Tests Traditional Tests

9. Nanodevices Can Make Cancer Tests Faster and More Efficient Patient APatient B

10. Cantilevers Can Make Cancer Tests Faster and More Efficient Cancer cell Water molecule Nanodevices Cantilevers Antibodies with proteins Antibodies White blood cell Bent cantilever

11. Nanopores A Single- stranded DNA molecule Single-stranded DNA molecule White blood cell Water molecule Nanodevices Nanopores Single-stranded DNA molecule ATCGATCG Nanopore T

12. Quantum Dots Ultraviolet light off White blood cell Water molecule Nanodevices Quantum dots Quantum dots emit light Ultraviolet light on Quantum dots Quantum dot bead

13. Quantum Dots Can Find Cancer Signatures Cancer cells Healthy cells Quantum dot beads Healthy cells Cancer cells

14. Improving Cancer Treatment Nanotechnology TreatmentTraditional Treatment Intact noncancerous cells Noncancerous cells Toxins Nanodevices Cancer cells Dead noncancerous cells Noncancerous cells Drugs Dead cancer cells Dead cancer cells Toxins Cancer cells

15. Nanoshells Nanoshell White blood cell Water molecule Nanodevices Nanoshells Gold Near-infrared light onNear-infrared light off Nanoshell absorbs heat

16. Nanoshells as Cancer Therapy Nanoshells Dead cancer cells Nanoshells Cancer cells Healthy cells Intact healthy cells Near-infrared light Healthy cells Cancer cells

17. Nanodevices as a Link Between Detection, Diagnosis, and Treatment Nanodevice Reporting TargetingDetection Imaging NanoBiotechnology Cancer Treatment Cancer cell Traditional Cancer Treatment Cancer cell Drug

18. Dendrimers Dendrimer White blood cell Water molecule Nanodevices Dendrimer Cancer cell

19. Dendrimers : Highly Branched Dendritic Macromolecules

20. ● Characteristics  Monodisperse macromolecule  Globular (Spherical)  Facile surface bio-functionalization  Similar molecular size to biomolecules (Glucose oxidase 6  5.2  7.7 nm) Molecular carriers for chemical catalysts (Core, Peripheral) Medical applications (MRI contrast enhancer) Biomimetic catalysts (Peptides-, Glycodendrimers) Vehicles for delivery of genes and drugs Poly (amido amine) Dendrimers 4.5 nm G4 Poly(amidoamine) Dendrimer ● Applications

21. Dendrimers as Cancer Therapy Cell death monitor Reporter Therapeutic agent Cancer detector Water molecule White blood cell Nanodevices Dendrimer

22. NanoBiotechnologies in Patient Care Today2020

23. We would like to hear from you... If you have questions about this tutorial’s content, suggestions for new topics, or other feedback on the Web site, please send an e-mail to kerrigad@mail.nih.gov. If you have questions about this tutorial’s artwork or want permission to use it, please send an e-mail to beankelly@verizon.net.