1. BIMM118 Drugs Targeting the CNS Parkinson Epilepsy Hypnotics General Anesthetics Anxiolytics Antidepressants

2. BIMM118 Diabetes mellitus Pancreas: Islets of Langerhans: site of hormone production –A (alpha) cells – produce Glucagon –B (beta) cells – produce Insulin –D (delta) cells – produce Somatostatin Insulin and Glucagon are the major regulators of blood glucose

3. BIMM118 metronidazole Protozoal infections Anaerobic organisms C. difficile Patient should not have alcohol

4. BIMM118 Antifungal Amphotericin B – drug for systemic fungal infections Given IV – for very serious infections Causing leakage of intracellular cations in fungal cells Must be given for several months

5. BIMM118 Adverse effects Infusion reactions – pretreat – locally change IV sites Nephrotoxicity – almost all patients will have some degree Lipid-based formulas cause less nephrotoxicty (much more expensive) May be given with flucytosine – can reduce dose of Ampho – decrease side effects

6. BIMM118 Acyclovir Infections caused by herpes simplex viruses and varicella zoster virus Suppresses synthesis of viral DNA – inhibits viral replication

7. BIMM118 Therapeutic use Genital herpes – topical and oral for recurrent Mucocutaneous herpes simplex infections – face and oropharynx Varicella-zoster – shingles and chickenpox

8. BIMM118 Adverse effects Typically well-tolerated Oral – GI, rash dizziness IV – phlebitis, inflammation, reversible nephrotoxicity

9. BIMM118 END Return to Course Site