1. Angelman and Prader Willi Syndromes
Hannah Messier and Cecily Fogarty

2. Background of Angelman Syndrome
Discovered in 1965 by Harry Angelman.
First called Happy Puppet Syndrome
University of Florida
Cause of disease was found in 1967

3. History of Prader Willi Syndrome
Genetic disorder on chromosome 15 where 7 genes are not expressed.
Discovered by Andrea Prader and Heinrich Willi in

4. What happens to those who have Angelman Syndrome
Intellectually grows slower than others
Mental issues
Seizures
Walking
Talking disabilities
Attention issues
Hyper
Generally Happy
Are easily excited

5. What happens to those with Prader Willi Syndrome
Low muscle tone
Short stature
Small genitalia, hands and feet
Cognitive disabilities
problem behaviors
Chronic feeling of hunger (linked with obesity)

6. How is Angelman Syndrome Passed on?
Caused by an issue with the 15th chromosome
Deletion
Mutation

7. How is Prader Willi Syndrome Passed on?
Usually the father is the one who was missing the chromosome.
Yet it has been reported that some with this disorder have a unique chromosome 15 because both strands come from the mother instead of one strand from the mother and one from the father.

8. Pictures

9. Other Interesting information about Angelman Syndrome
Only females can cause the syndrome.
Males can pass the mutation on but the child won’t have the syndrome.
1/12000 people

10. Other interesting information about Prader Willi Syndrome
This serious syndrome occurs in 10,000 out of 25,000 live births.
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If you know someone with this syndrome or anyone who may have this syndrome please help them by showing them this website.

11. Works Cited
Angelman Syndrome Foundation Inc. Angelman Syndrome Foundation. Global Cloud. Web. February 20, 2013.
Genetic Lens. “History of the Diagnosis.” The Angelman Project, Web. February 24,
"Angelman Syndrome." - Genetics Home Reference. N.p., n.d. Web. 24 Feb
Board, A.D.A.M. Editorial. Prader-Willi Syndrome. U.S. National Library of Medicine, 18 Nov Web. 24 Feb
"Prader-Willi Syndrome." Medical Information & Trusted Health Advice: Healthline. N.p., n.d. Web. 24 Feb