1. Formerly known as “91 Turkish” and part of the abandoned RJ Reynolds Tobacco Co. manufacturing complex, the historic rehabilitation of this property initiated the urban revitalization of the north district of the Wake Forest Innovation Quarters into a vibrant research and innovation center. “Wake Forest Biotech Place”, designed to support the Wake Forest Baptist Medical Center’s expanding research departments and technology spin-offs, houses over 250,000sf of offices and labs, and plays host as a regional conference center. The tax credits that became available as a result of the meticulous restoration of the glass block façade (deemed one of the first full building glass block facades in the country by the National Park Service) and preservation of the building’s industrial character, created the economic feasibility for this landmark project. A large 75,000sf footprint fostered the creation of a 7,000sf 3-story glass enclosed atrium and daylighting strategies to support the various research neighborhoods and the an energy efficient “chilled beam” cooling plant made the building a LEED Gold recipient. This revitalization has become a destination in downtown Winston-Salem and a signature for future redevelopment in this former manufacturing district. North District of the “Wake Forest Innovation Quarter” A 1940 era photograph: 91 Turkish Aerial view of the former Reynolds manufacturing plant and Turkish 91 (now known as Wake Forest Biotech Place). Project Description and Introduction 525@Vine Street Revitalized Multi-tenant and Medical Education Center Innovation Park Future Wake Forest School of Medicine Bailey Power Plant – Future Movie Theater and Restaurant Center Vine Street 5 th Street 6th Street Patterson Street Location: Winston-Salem, NC Name: Wake Forest Biotech Place Photos: Tom Holdsworth Photography

2. Turkish 91: A former tobacco factory breathes new life “sciences”. The National Trust for Historic Preservation honors as one of the 10 most significant restoration projects of the year. Wake Forest Biotech Place Winston-Salem, NC

3. 15 foot glass block walls The National Park Service required that the original full story height walls of 15 feet high glass block be maintained, and repaired for authenticity, demanding state of the art efficient HVAC systems. Severely damaged two-piece glass block (sealed with lead) were surgically repaired and reinstalled. A view of the abandoned building in 2008 before construction. 16 x 24 foot concrete column grid Massive clean up and demolition was required to remove old 1930 (and beyond) vintage Reynold’s tobacco and stage the building for the revitalization. The surgical removal of a 75,000 sf floor was performed and replaced 18 inches higher in order to make the floor to floor dimensions acceptable for the new research operations. The massive floor structures and columns placed on a 16 x 24 foot grid were maintained and the interior developed around to preserve the character of the industrial environment. Historic Conditions

4. Before After Before The art deco entrance cast stone facades and steel curtain wall added in the 1950s were restored to their original conditions. Patterson Street – West Elevation 6 th Street – North Elevation 5 th Street – South Elevation 1950s Addition Vine Street – East Elevation Original 1937 Building The National Park Service permitted more liberal alterations to the 1950s wing exterior in consideration of the extreme efforts to restore the 1937 building.

5. 11Common Collaborations 12Atrium Stair 13Vivarium Research Level 2 East – West Section (EW) Level 4 Level 1 Level 5 Level 3 Floor Levels 4 and 5 Similar / Not shown Legend:1Atrium Commons 2Entrance / Retail 3Office / Laboratories 4Offices / Marketing Center 5Service / Loading 1 1 2 3 3 4 3 5 6 6 8 8 8 8 9 10 6Commons / Conference 7Classrooms 8Research Neighborhood 9Main Entrance Lobby 10Skylight 12 11 3 3 13 10 North - South Section Looking East (NS) Level 2Level 3Level 1 7 NS 1 EW 1 3 3 3 3 2 3 4 7 3 9 5 5

6. The restored glass block façade is illuminated at night and serves as a welcoming “beacon” to residents that the neighborhood revitalization is alive. View from Patterson and 5 th Street Vine Street – East Elevation 5 th Street Public TerraceAtrium CommonsPatterson Street – West Elevation Exterior Revitalization

7. Atrium Commons Before After Atrium Overlook2 nd Break Collaboration AreaAtrium Commons

8. The restored glass block façade seen “reflected” at Marketing Center Conference Room Frameless Glass Walls Designed to Open Sight Lines to Restored Glass Block Before After Laboratory Along Restored Glass Block Wall Interior Revitalization

9. Wood floors were reclaimed and reused throughout the building and steel framing was created to replicate former industrial fabrications in the building. Interior Revitalization

10. The Research Neighborhoods serve a wide variety of scientists and departments from the Wake Forest Medical Center, clustered to foster faster translational research through a multi-disciplinary team approach. Wake Forest Biotech Place will house over 500 faculty, scientists, graduate level students, private industry medical research and device companies, non-profit institutes and new business accelerators. Retail tenants include a bank and full – service café. “….from a tobacco factory to a state-of- the-art medical village………