1. THE CITRIC ACID CYCLE
Kadek Rachmawati

2. The citric acid cycle = Kreb’s cycle = Tricarboxy-
lic acid cycle a series of reactions that oxidized Asetyl-CoA
Occur in Mitochondria
To yield energy (ATP)
TCA cycle the final common pathway for the aerobic oxidation of carbohydrate, lipid and protein

3. TCA cycle is common pathway for carbohydrate, lipid and protein

4. TCA cycle pathway

5. The function of TCA cycle :
1. Oxidized of Acetyl CoA ATP
( 1 mol Acetyl CoA mol ATP )
2. The citric acid cycle is AMPHIBOLIC :
- it can oxidized to yield ATP
- it is important in the provision of carbon skeletons for gluconeogenesis, fatty acid synthesis and interconversion of amino acid

6. Vitamins play key roles of the Citric Acid Cycle
Four of the B vitamins are essential in the citric acid cycle :
1. Ribovlavin FAD
2. Niacin NAD
3. Thiamin TPP
4. Pantothenic acid CoA
The B vitamins are essential in energy yielding metabolism by dehydrogenase enzyme :
- FAD mol ATP
- NAD mol ATP

7. INHIBITOR OF TCA CYCLE 1. Fluoroacetate
Condensation with CoA Fluoroacetyl-CoA
Condensation FluoroacetylCoA with Oxaloace-
tate Fluorocitrate inhibit Akoni-
tase enzyme accumulation of citrate
Fluoroacetate pesticide
2. Malonate suksinat dehydrogenase enzyme
3. Arsenite α-ketoglutarate dehydrogena-
se enzyme

8. Participation of TCA cycle in fatty acid synthesis from glucose

9. Involvement of TCA cycle in transamination and gluconeogenesis

10. REGULATION OF TCA CYCLE

11. REGULATION OF TCA CYCLE

12. REGULATION OF TCA CYCLE

13. REGULATION OF TCA CYCLE

14. Thank You