1. Automated Metered Dose Inhaler Presented By Group 11: The “MDI Auto-Maniacs” Maria del Carmen Carrillo Jennifer B. Struble Loyrirk Temiyakarn

2. Background What is a Metered Dose Inhaler? What is a Metered Dose Inhaler? pocket-sized handheld inhaler delivers standardized dose of medication for bronchodilation Who Uses Them? Who Uses Them? Patients with asthma or chronic obstructive pulmonary disease (COPD) Setting? Setting? Critical patients in hospitals Critical patients in hospitals Prescriptions for outpatient or in-home use Prescriptions for outpatient or in-home use

3. Problem Definition Automatic Metered Dose Inhalant (MDI) delivery device: Automatic Metered Dose Inhalant (MDI) delivery device: Electromechanical, in-hospital inhalant drug delivery system Electromechanical, in-hospital inhalant drug delivery system Patients are mechanically ventilated and sedated Patients are mechanically ventilated and sedated Medication delivered automatically as prescribed electronically Medication delivered automatically as prescribed electronically Medication must be well shaken (homogenized with propellant) Medication must be well shaken (homogenized with propellant)

4. Design Factors Integration with existing endotracheal tubing Integration with existing endotracheal tubing Homogenization with propellant Homogenization with propellant Delivery of medication into ventilation system Delivery of medication into ventilation system Tubing length Tubing length Synchronization of delivery with breathing Synchronization of delivery with breathing Software/Automation Software/Automation User interface User interface Prescription error checking Prescription error checking

5. Project Status Preliminary Research Complete Standard MDI Completed Research Endotracheal Tubing Connectors Ventilators Types of Medication Continuing Research Homogenizer

6. Working Design: Using Prefabricated Canisters Integrated with existing tubing Integrated with existing tubing T connector T connector Homogenize Homogenize Vortexer Vortexer Phone Vibrator Phone Vibrator Spring-Loaded Agitator  Spring-Loaded Agitator  Laptop-based prescription entry Laptop-based prescription entry Similar to error reduction system, Guardrails® Safety Software, in Alaris “Smart” IV Pump Similar to error reduction system, Guardrails® Safety Software, in Alaris “Smart” IV Pump

7. Working Design: For Liquid Medication Integrate with existing tubing AnaConDa™ Hudson RCI Homogenize Not Needed Need evaporator and filters Automated Genie Syringe Pump Kent Scientific

8. Timeline Completed Work Completed Work Preliminary research Preliminary research Clearly defined design factors Clearly defined design factors Through Innovation Workbench Through Innovation Workbench Current Work Current Work Order more components to start building prototype Order more components to start building prototype Tubing, Vibrator, AnaConDa™ Tubing, Vibrator, AnaConDa™ Testing distance were adequate dose is still administered through tubing Testing distance were adequate dose is still administered through tubing Building Model A Building Model A Projected Timeline Meeting with local contact (Anna Ambrose) next week Testing ~ First week of February Implement corrections Model B ~ Second week of March Software included Testing ~ End of March Final prototype ~ April

9. References http://familydoctor.org/040.xml http://familydoctor.org/040.xml http://familydoctor.org/040.xml http://www.medlineplus.com/ http://www.medlineplus.com/ http://www.medlineplus.com/ http://www.alarismed.com/na/press/presskit_ bkgd.shtml http://www.alarismed.com/na/press/presskit_ bkgd.shtml http://www.alarismed.com/na/press/presskit_ bkgd.shtml http://www.alarismed.com/na/press/presskit_ bkgd.shtml http://www.drgreene.com/21_1377.html http://www.drgreene.com/21_1377.html http://www.drgreene.com/21_1377.html http://www.med.umich.edu/anes/tcpub/glossa ry/anesthesia_glossary-05.htm http://www.med.umich.edu/anes/tcpub/glossa ry/anesthesia_glossary-05.htm http://www.med.umich.edu/anes/tcpub/glossa ry/anesthesia_glossary-05.htm http://www.med.umich.edu/anes/tcpub/glossa ry/anesthesia_glossary-05.htm http://www.rattus.com/catalogpagesearch5ak ent.asp?page=5 http://www.rattus.com/catalogpagesearch5ak ent.asp?page=5 http://www.rattus.com/catalogpagesearch5ak ent.asp?page=5 http://www.rattus.com/catalogpagesearch5ak ent.asp?page=5 Hudson RCI. AnaConDa™ Principles of Operation. 2003 Hudson RCI. AnaConDa™ Principles of Operation. 2003