1. Project Funding & New Projects Cancer Care Engineering

2. Project Funding U.S. Army Medical and Materiel Command – $2.3M – Negotiating new $2.15M award Regenstrief Foundation – $1.35M Walther Cancer Foundation – $1.8M NIH (2) and DoD (1) pending

3. New Projects Army Funding Sample Diversification – Increasing sample sites to increase power of predictive models – Population diversification Create a Statewide Infrastructure – Partner with Clarian Health Pilot with Clarian Arnett in Lafayette Create a Community Research IRB

4. New Projects in WCCE Army Funding Epidemiology and Visualization Project – Ebert (Purdue), Swanson and Champion (IUSCC) – Develop visual analytic tools for Indiana- based colon cancer-related epidemiological data.

5. New Projects in WCCE Army Funding Molecular Characterization of CRC Samples – Stan Hamilton (MD Anderson) Economic Evaluation of Colorectal Cancer – Mick Murray (Purdue, Regenstrief)

6. New Projects Walther Embedding Program $1M Award over 5 years – Matched by $0.5M (IUSCC and Purdue) Objective: – Create a culture for the effective exchange of knowledge to allow clinical perspectives to drive the design of new chemistries, engineered devices/structures and mathematical predictive models that will make a critical difference in delivering effective cancer treatment.

7. New Projects Walther Embedding Program Create “Research Embedding Teams” – first year engineering or physical sciences postdoctoral fellow, – medical fellow, – Indiana University Simon Cancer Center (IUSCC) oncology faculty mentor – Purdue Physics/Chemistry/Engineering faculty mentor Teams submit 2 page project descriptions detailing joint project. Selected projects will be awarded: – Funds provided to cover both postdoctoral and medical fellow’s salaries – Project funds (up to $100K) Embed physical sciences and engineering Postdoctoral Fellows in the clinics at the IUSCC Embed medical fellows in engineering, chemistry or physics laboratories at Purdue

8. New Projects Genomics of CRC Walther Cancer Foundation $326K over 2 years Partnership with Notre Dame Expression analysis on CRC tissues – Prediction of severity of the tumors – Integration of data to ID biomarkers of particularly virulent colon cancer – Overexpressed gene targets selected and functionally evaluated with RNAi based approaches

9. Project Long Term Goals Provide Instantaneous Communication Vehicle Stratify Patients – Disease Risk – Prevention Strategies – Response to Therapy – Clinical Trials ID and Validate Clinically Relevant Biomarkers ID Therapeutic Targets – Targeted Therapies & Diagnostic Tests ID Barriers to Effective Healthcare Delivery

10. Cancer Care Engineering A Systems Approach to the Prevention & Treatment of Cancer Marietta Harrison harrisom@purdue.edu 765-494-1442