1. National Centre for Text Mining John Keane NaCTeM Co-director University of Manchester

2. Welcome To All JISC, BBSRC, EPSRC National Agencies (British Libraries, HMCE, MoD) Regional Agencies Industry (pharmas etc, software related, etc) Academic community (Univs, DCC, CURL etc) Thanks to the host institutions Thanks to: Anne Trefethen Ross King Leona Carpenter

3. Funding Bodies, Community etc Thanks to the funding bodies (JISC (JCSR), BBSRC, EPSRC) and the UK and international Text Mining Community For recognition of potential impact and significance of Text Mining on the bio- sector and wider academic community, and for articulating need for a National Centre

4. Invited Speakers/Panellists Terri Attwood, University of Manchester Clifford Lynch, Coalition for Digital Information Rob Procter, National Centre for e-Social Science Dietrich Rebholz-Schuhmann, European Bioinformatics Institute

5. Self-funded Partners University of California, Berkley Ray Larson University of Geneva Margaret King University of Tokyo Jun-ichi Tsujii San Diego Supercomputer Centre Reagan Moore

6. Involvement MANCHESTER Bill Black; Informatics Julia Chruszcz; MIMAS, Manchester Computing Carole Goble; ESNW and Computer Science John McCarthy; MIB and Faculty of Life Sciences John McNaught; Informatics LIVERPOOL Paul Watry; University Library and Dept of English SALFORD Sophia Ananiadou; Computing, Science and Engineering Wendy Johnson, now MerseyBio

7. Text Mining – definition Auvril and Searsmith (Illinois) 2003 Non trivial extraction of implicit, previously unknown, and potentially useful information from (large amount of) textual data Exploration and analysis of textual (natural- language) data by automatic and semi automatic means to discover new knowledge and update existing knowledge What is previously unknown information? –Strict: Information that not even the authors knew –Lenient: Rediscover the information that the author encoded in the text

8. TERM & INFORMATION EXTRACTION USER INTERFACE ONTOLOGIES DATA MINING INFORMATION RETRIEVAL USERS TEXT MINING MEDICINEMEDICINE ENGINEERINGENGINEERING SCIENCEDIGITAL LIBRARIES BIO-SCIENCE HUMANITIES

9. Text Mining – vision (Bio)DBs with accurate, valid, exhaustive, rapidly updated data –only 12% of TOXLINE users find what they want –significant error rate and gaps in manually curated data Drug discovery costs slashed; animal experimentation reduced through early identification of unpromising paths –$800M over 12 years to develop a new drug -> reduce by 2 years New insights gained through integration and exploitation of experimental results, (bio)DBs, and scientific knowledge Product development archives and patents yield new directions for R&D Searching yields FACTS rather than documents

10. Text Mining – realism Computerworld 2004 Technical: Technology is becoming mature but issues of efficiency and scalability – need to integrate myriad set of tools Person-intensive: Skill set required to understand domain (e.g. develop ontology) and interpret/analyse results

11. NaCTeM so far … £1M over 3 years (review after 2 years) – co-funding by institutions of ~£800K 6 core staff – joined October04-January05 Requirements gathering and technical development phases begun UGeneva have received funding for part-time post on evaluation Planned move to Manchester Interdisciplinary Biocentre in summer 2005. Thanks to all involved, and the NaCTeM team, in particular Richard Barker for organising