1. IAN Test Drive

5. Baylor Principal Investigator: Dr. Robin Goin-Kochel Study Title: Autism Treatment Network Location: Baylor College of Medicine/Texas Children's Hospital Inclusion: 1. Children between the ages of 3.0 –17.9; the subject will be expected to complete the protocol by his/her eighteenth birthday. 2. Parent/Caregiver fluent in written and spoken English/ English spoken in the home with the child at least 75% of the time (because most assessment questionnaires are validated in English only). (Additional inclusion criteria, such as having an ADI-R/ADOS confirmed ASD diagnosis, will be done at the ATN site.) Exclusion: 1. Blindness precluding valid testing. 2. Deafness precluding valid testing. 3. Ongoing or planned participation in another research protocol that would either prevent successful completion of planned study testing or invalidate the results of study testing.

6. Baylor

7. 300 Subjects

8. Baylor

10. University of Iowa Principal Investigator: Dr. Karla McGregor Study Title: The Development of Word Meaning Location: University of Iowa Catchment area: Iowa or 100 miles of Iowa City Inclusion: chronological age = 8 to 13 years; verbal; high- functioning (not mentally retarded); normal hearing acuity Exclusion: none Sample size: 30

11. Iowa

14. Multi-Center Baby Sibs Study Principal Investigator: Dr. Joe Piven et al Study Title: Brain Development in Infants at High Risk for Autism Location: (Multi-center) University of North Carolina at Chapel Hill, Washington University, University of Washington, Yale University Inclusion: under 12 months of age; at least one older sibling with a documented diagnosis of autism Exclusion: * Certain medical and genetic conditions * MRI contraindication * Non-English speaking

15. Baby Sibs (ACE Study, Joe Piven et al) N=160

19. Exploring the Treatment Data

20. Treatments

21. Top Twelve Treatments Nationwide 1.Speech and Language Therapy 2.Occupational Therapy 3.Applied behavior analysis (ABA) 4.Social Skills Group 5.Picture Exchange Communication System (PECS) 6.Physical Therapy 7.Visual Schedules 8.Sensory Integration Therapy 9.Social Stories 10.Risperdal 11.Casein-free diet 12.Melatonin

22. InterventionImprovementExpected Improvement Expected Risk Expected Burden N Keppra2.83.72.62.115 Ritalin2.73.42.62.132 Feingold diet2.72.81.13.415 Homeopathy2.5 1.62.423 Melatonin2.52.91.71.5179 Clonidine2.53.22.21.9135 DTT2.43.51.42.6115 Prayer2.42.91.11.2133 Remeron2.43.32.51.911

23. Parental Age

25. Moternal Age

26. 32.8 33.0 P=0.5 MaleFemale

28. Action Points Recruit Analyze Write Suggest/Author New Content