1. A prognostic model for lymph node negative breast cancer patients by Integrating proliferation and immune response Supplementary figures

2. Supplementary Fig. S1 7.9% 73%

3. samples GSE12093 PC1 (proliferation) PC2 (immune response) Supplementary Fig. S2 A B 23.8% 8.7% 4.2% 3.7% GSE11121GSE2034GSE7390

4. M phase Cell cycle phase Nuclear division Mitosis M phase of mitotic cell cycle Organelle fission Cell cycle process Mitotic cell cycle Cell cycle Cell division Chromosome segregation Organelle organization Cytoskeleton organization Spindle organization Sister chromatid segregation 0.01 0.00 p value Supplementary Fig. S3 A

5. Immune response Immune system process Response to stimulus Lymphoid organ development Response to other organism Antigen processing, presentation Defense response Respons e to biotic stimulus Chemotaxis Taxis Inflammatory response Regulation of immune process Locomotory behavior Lymphocyte differentiation Hemopoiesis T cell selection Leukocyte differentiation Cell activation Multi- organism process 0.010.00 p value Supplementary Fig. S4 B

6. Supplementary Fig. S5 18%19% 24%27% 48% 31% 46%43%38%40% 31% 51% 37% 33% 21%18% ER+ ER- Proliferation low expression of i.mean (i1) medium expression of i.mean (i2) high expression of i.mean (i3)

7. p = 0.004 ER- p = 0.31p = 0.001 p = 0.022 p = 0.984 p = 0.912 Supplementary Fig. S6 ABC DE F

8. BA C Supplementary Fig. S7