1. Neonates Dr.I.Lakshminarayana

2. Structure Normal new born Adaptation to extra uterine life Nutrition Maintaining temperature Common neonatal problems Neonatal examination Case discussion

3. Anthropometry Term 37-42 weeks Pre term < 37 weeks Post term >42 weeks Normal birth weight 2.5- 4 kg (average 3.5 kg/7.5 pounds) Low birth weight <10 th centile ELBW <0.4 th centile Head circumference average 35 cm Length 50 cm

4. Normal to lose weight 5-7% in first ten days From then on babies gain 15 g/day

5. The transition-Respiratory In utero fetal lung is filled with fluid 25ml/kg Compression of chest wall during delivery Chemoreceptor stimulation causes a gasp (<6sec) Sensory stimulation Clamping cord will increase the systemic pressure and reduce pulmonary pressure.

6. Transition-cardiovascular UV through ductus venosus to IVC IVC RA RV,PA,Aor Thro FO To LA

7. Changes in circulation at birth Cord is clamped, collapse of veins and ductus venosus, increase in sytemic pressure Ist breath lungs expand, vasodilation, pulmonary vascular resistance falls by 80%,increase in LA pressure, closure of FO Ductus arteriosus closes owing to rise in Pao2 by 12 hours

8. Nutrition Breast is best Advantages of breast feeding- Protects against respiratory/gastrointestinal infections Increases response to immunisation Reduces risk of NEC Reduces incidence of allergy and atopy Increases cognitive development

9. Nutritional requirement Term babies require 100kcal/kg/day Breast milk provides 70kcal/100ml 1.3 gm protein,4.1 gm fat,7.2 gm carbohydrates

10. Breast milk composition Fat –supply energy, build cell membranes, LCPUFA, EFA help in cognitive development and improved retinal function Carbohydrates – Lactose converted to lactic acid by lacto bacillis protects gut Protein – Whey based easily absorbed, antibodies, lactoferrin, enzymes

11. Maintaining temperature Cold can kill Ideal temperature close to 37 Heat loss can occur due to large surface area for a small body mass Heat loss occurs by conduction, convection, evaporation and radiation Heat production- hydrolysis of triglycerides in brown fat using oxygen

12. Clinical effects of hypothermia Reduced surfactant synthesis Reduced surfactant efficiency Hypoglycemia Increased oxygen requirement Increased utilisation of calorie reserves Increased postnatal weight loss

13. Common neonatal problems Benign

14. Birth Marks

15. Rash

16. Other problems Feeding Hypoglycemia Jaundice

17. Know basic physiology of bilirubin metabolism Day 1 jaundice always pathalogical commonest cause being blood group incompatability Prolonged jaundice>14 days think could this be obstructive High bilirubin levels cause kernicterus

18. Problems that need immediate attention Respiratory TTN, RDS, Meconium aspiration, congenital pneumonia, CDH Infection GBS, Staphylococci,E.Coli, Listeria Cardiac causes Duct dependant systemic /pulmonary circulation

19. Congenital anomalies of gut – duodenal atresia, anal atresia,NEC in preterm infants.

20. New born examination History –mother’s medical,antenatal history, FH of heart disease, DDH Explore parental concerns, feeding Check weight, HC, length and plot on chart Detailed head to toe examination with infant undressed with particular emphasis in picking up birth trauma and congenital abnormalities Examine eyes, hips

25. Case discussion 32 hour old baby referred by midwife for jaundice What questions would you ask the mother? How will you manage this baby? How will you monitor treatment?

26. 3 week old baby referred for prolonged jaundice What are the likely causes What condition you would like to rule out? What investigations would you perform?

27. You are the FY1 in neonates. You are called by the midwife to review a baby who is 15 minutes old. She is concerned that the baby is grunting. What are the initial questions you will ask the midwife? What are the causes of respiratory distress in babies? What are the investigations you will request? How will you manage this baby?