1. The Effects of Respiratory tract cleansing and pursed-lip breathing rehabilitation exercise on subjective physical symptoms in Middle-Aged and Older Chronic Obstructive Pulmonary Disease with Acute Exacerbation in Taiwanese 高齡長期照護海報展 Lin-Yu Laio 1, Jung-Yien Chien 2, Kuei-Min Chen 3 Chest Hospital, Department of Health Executive Yuan 1,2 Kaohsiung Medical University of Professpor 3 Kaohsiung Medical University of PHD Student 1 Background Purpose The role of respiratory tract cleansing and pursed-lip breathing in patients with COPD AE is still on clear. We aim to evaluate the effect of respiratory tract cleansing and pursed-lip breathing rehabilitation exercise program in patients with COPD AE. Methods Study design:A quasi-experiments pre-test post-test, a convenience sample will be conducted at chest hospital in southern Taiwan. Sample size were 61 patients Respiratory rehabilitation group/Control group 30 patients a 4 days respiratory tract cleansing and pursed-lip breathing rehabilitation of twice a day and a control group of 31 subjects received the general care. Data were collected before and after the intervention Measurements/Dataanalysis:Subjective physical symptoms score included anxiety, dyspnea, cough, and fatigue were measured. Inclusion/exclusion criteria : Average age ＞ 18 years, conscious clear and speak Chinese, Can walk, and clinical stable were included. Exclusion criteria were hemoptysis and spo2 ﹤ 90%. Results Implication for practice Key Words: respiratory tract cleansing, pursed-lip breathing rehabilitation, chronic obstructive pulmonary disease with acute exacerbation Base on the results of this study, can implies that the program may provide used nursing guidance for COPD middle-aged and elders with acute exacerbation stage ●The baseline conducted were similar between two groups. ●lower anxiety score was lower at 2th,3th,4 th days(4.81±4.00 、 5.10±3.83 、 4.68±3.66 for control group, 2.93±2.70 ， 2.83±2.51 ， 2.33±2.12 for rehabilitation group) ●lower dyspnea score at 3th,4 th days(3.68±3.31 、 3.65±3.25 for control group, 2.90±2.51 、 1.73±1.60 、 1.13±1.22for rehabilitation group) ●lower cough score at 3th,4 th days(5.00±3.12 4.68±3.15 for control group, 3.17±1.72 、 2.07±1.14 for ehabilitation group) Table Fatigue difference between respiratory rehabilitation group and control group of61 COPD with AE time Control group n=31 respiratory rehabilitation group n=30 tP M±SD Besline12.81±5.7110.67±4.301.651.104 after admission 1th day12.48±6.146.93±2.074.702.000 after admission 2th day11.26±5.206.93±2.154.222.000 after admission 3th day10.29±4.856.57±2.613.719.000 ● lower fatigue score at 2th,3th,4th days (12.48±6.14 、 3.68±3.31 、 10.29±4.85for control group, 6.93±2.07 、 6.93±2.15 、 6.57±2.61for rehabilitation group). Table C0ugh difference between respiratory rehabilitation group and control group of61 COPD with AE time Control group n=31 respiratory rehabilitation group n=30 tP M±SD Besline5.26±3.4445.30±2.600.054.957 after admission 1th day5.29±3.4474.33±2.711.203.234 after admission 2th day5.00±3.123.17±1.722.827.006 after admission 3th day4.68±3.1452.07±1.144.28.000 Table Dyspnea difference between respiratory rehabilitation group and control group of61 COPD with AE time Control group n=31 respiratory rehabilitation group n=30 tP M±SD Besline4.13±3.324.5±2.500.491.625 after admission 1th day4.13±3.322.9±2.511.626.109 after admission 2th day3.68±3.311.73±1.562.906.005 after admission 3th day3.65±3.251.13±1.223.967.000