1. Host-Parasite Relationship Normal Flora Pathogens Infections Opportunistic pathogens

2. Skin Flora 180 species Streptococcus Staphylococcus Propionibacterium Body Odor Acne

3. Oral Cavity Flora Plaque Anaerobes Biofilms Dental Caries Streptococcus mutans, sobrinus Sucrose

4. Tongue

5. Intestinal Tract Stomach – pH Helicobacter pylori Small Intestine Enterococci, Lactobacilli

6. Large intestine 10 10 -10 11 cells/gm Bacteroides Enterobacteria Escherichia coli Enterococcus

7. Large Intestine Flora Methanogens Food passage 24 hrs Excrete 10 13 /day Probiotics Fecal transplant

8. Respiratory Tract Staphylococcus aureus Streptococcus pneumoniae S. pyogenes Corynebacterium diphtheriae Carrier

9. Opportunistic Pathogens E. coli Virulence Invasiveness Toxicity Lactobacillus acidophilus Urogenital Tract

10. Adherence Specific Adherence Capsule Slime Layer Glycocalyx Fimbriae Pili - longer

11. Invasiveness Colonization Factor Antigen Invasion Colonization Iron- Siderophore Bacteremia vs. Septicemia

12. Enzymes & Toxins Coagulase Collagenase Exotoxins Cytolytic Toxins Hemolysins, Leukocidins Diphtheria Toxin Botulism Toxin Tetanus Toxin Tetanus

13. Enterotoxin Cholera toxin Endotoxin – Pyrogen LD 50 Virulence Factors Attenuated Strains Other Toxins Pyrogen free Products

14. Virulence Factors

15. Nonspecific Host Defense Natural Resistance Age Stress Diet Anatomical Defenses Skin, Stomach, Tears

16. Compromised Hosts Inflammation Fever Nosocomial Infections

17. Host-Parasite Word List Normal Flora Pathogens Infection Skin Flora Staphylococcus, Propionibacterium Oral Cavity Flora Plaque Streptococcus spp Dental Caries Streptococcus mutans Intestinal Tract Stomach – pH2 Helicobacter pylori Small Intestine Enterococci, Lactobacilli Large Intestine 10 10 - 10 11 cells/gram

18. Host-Parasite Word List 2 10 10 - 10 11 cells/gram Bacteroides, Enterobacteria, Escherichia coli, Enterococcus Respiratory Tract Staphylococcus aureus, Streptococcus pneumoniae, S. pyogenes, Corynebacterium diphtheriae Carrier Urogenital Tract Opportunistic Pathogens Virulence Invasiveness, Toxicity Specific Adherence

19. Host-Parasite Word List 3 Capsule, Glycocalyx, Slime Layer Fimbriae, Pili Colonization Factor Antigen Invasion Colonization Iron – Siderophore Bacteremia – Septicemia Enzymes & Toxins Coagulase, Collagenase Exotoxins Cytolytic Toxins Hemolysins, Leukocidins

20. Host-Parasite Word List 4 Diphtheria Toxin Botulism Toxin Tetanus Toxin Enterotoxin Cholera Toxin Endotoxin LD 50 Attenuated Nonspecific Host Defenses Natural Resistance Age, Stress, Diet Anatomical Defenses Skin, Stomach, Tears

21. Host-Parasite Word List 5 Compromised Host Inflammation Fever