1. Tinatin Bukia Tinatin Bukia Synthesis some of Bioactive Adamantane Fragment Containing New Peptides Via Ugi- Reaction

2. Ugi reaction Ugi reaction

3. Ugi reaction mechanism

4. AGENTTHERAOEUTICAL USE Potential peptide and protein drug Amylin Diabetes and nutrition regulation Calcitonin Hyperoalcemia Ciclosporin Immunosuppressant Desmopressin Diabetes Epceitin Anemia Glucagon Hyperoalcemia Filgrastim Neutropenia Molgramostin Neutropenia Octreotide Pancreatitis Urofollitin Infertility Vasopressin Diabetes

5. Adamantan containing preparations

6. R 1 =C 6 H 5 CH 2 ; C 6 H 5 ; n-C 4 H 9 ; Ad; R 2 =i-C 3 H 7 ; C 4 H 9 ; R 3 =CH 2 -COOC 2 H 5 ; C 6 H 5 ;

8. Research subject :

9. Conclusion It is known by general the role of peptides in the modern medical practice. They are characterized wide spectrum of biological activity, which are widly used in the drug manufacture. By the biological activity are distinguished adamantane containing organic compounds, they are widely used in medicine as antiviral, antimicrobial, anticancerogenic, anticataleptic, immunotropic, neuropsychotropic and for a cure of other diseases. thus, the research and synthesis of adamantane containing new peptides is perspective and actual. The aim of our project Is to be continued research work about the syntheses of bioactive adamantane containing new peptides via Ugi- reaction.

10. THANK YOU ALL FOR ATTENTION!!!