2. ○ Vision And Objectives Through the Global 5-5-10 Project for Division of Dental Sciences, Yonsei University School of Dentistry will become one of the world’s leading educational and research institutes.

3. ○ Organization and Participants

4. Cell signaling Shin Dong MinLee Syng IllSeo Jeong TaegAhn Hyung Joon Tissue regeneration Jung Han SungPark Young ChelLee Sang HwyLee Seung Jong Lee Jae HoCho Sung WonChoi Byung Ho Digital imaging Kim Hee JinKim Kee DeogPark Chang SeoHu Kyung Seok Hwang Chung Ju Development of dental materials and medical devices Kim Kwang MahnKim Kyoung NamPark Sung HoLee Keun Woo Han Jong Hyun Periodontal disease and immune system Cha Jung HeonKwon Ho KwenKim Baek IlKim Chong Kwan Yu Yoon JungCho Kyoo SungChoi Seong Ho Carcinogenesis and cancer prevention Kim JinYook Jong InChung Won YoonPark Kwang Kyun

5. ○ Research Fields ● Cell signaling - Cell signaling associated with bone formation - Development of drugs that induce bone formation and prevent bone absorption prevent bone absorption Cell Signaling in Bone cells ▶ Cell signaling associated with bone remodeling ▶ Development of drugs to induce bone formation and prevent bone resorption

6. ○ Research Fields ● Tissue regeneration - Artificial tooth and bone formation using organ culture system using organ culture system - Orofacial hard tissue regeneration with an aid of artificial teeth and with an aid of artificial teeth and bones bones ▶ Construction of artificial tooth and periodontium

7. ○ Research Fields ● Digital imaging ▶ Development of diagnosis technique using digital image ▶ Data analysis using 3-D image ● Development of dental materials and medical devices ▶ Development and application of bioceramics for bone replacement ▶ Development of new dental casting metals

8. ○ Research Fields ● Periodontal disease and immune system ▶ Treatment and prevention of periodontal disease ▶ Drug development inducing periodontal tissue regeneration ▶ Research on the carcinogenesis ▶ Mechanism of Carcinogenesis ▶ Drug development for cancer treatment and prevention ● Carcinogenesis and cancer prevention

9. ○ Activities and Outputs ● Activities Student exchange program program ▶ Tokyo Dental college ▶ UCLA ▶ University of Pennsylvania Pennsylvania ▶ Tuft University ● Outputs ▶ Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development. Proc Natl Acad Sci USA, 103(45):16788-16793, 2006 ▶ A Wnt-Axin2-GSK3 cascade regulates Snail activity in breast cancer cells. Nature Cell Biology. 8(12):1398-1406, 2006 ▶ Xanthorrhizol inhibits 12-0-tetradecanoylphobol-13- acetate-induced acute inflammation and two-stage mouse skin carcinigenesis by blocking the expression of ornithine decarboxylase, caclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nucleas factor-kappa B. Carcinogenesis. 28(6):1224-1231, 2007 ▶ Skeletal muscle dressed in SOCs. Nature Cell Biology. 10(6):639-641, 2008

10. ○ Contact Point ● Director : Syng-Ill Lee, D.D.S., Ph.D. ● Address : Department of Oral Biology, Yonsei University College of Dentistry 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea ● Tel : +82-2-2228-3052 Fax : +82-2-364-1085 Fax : +82-2-364-1085 ● E - mail : lsi@yuhs.ac Website : http://bk21-dentsci.yonsei.ac.kr Website : http://bk21-dentsci.yonsei.ac.kr