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Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14.

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Presentation on theme: "Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14."— Presentation transcript:

1 Nitric Oxide Synthase 1.14.13.39 Cody A Scholtens CHE 442 10/21/14

2 Background L-Arginine + NADPH +H +  Citrulline +NO+ NADP + Neuronal NOS (1TLL) Endothelial NOS (2NES) Inducible NOS (1NOD)

3 Reaction Kinetics

4 Reaction Mechanism:

5 Crystal Structure

6

7 NOS (oxidation)

8 NOS (reduction)

9

10 Cofactors Flavin Dinucleotide (FAD) NADPH BH4 Tetrahydrobiopterin

11

12

13 Resources: 1.http://i1-news.softpedia-static.com/images/news2/Molecular-DNA- Switch-Found-to-Be-the-Same-for-All-Life-2.gif 2.http://www.rcsb.org/pdb/explore/explore.do?structureId=1TLL 3.http://www.rcsb.org/pdb/explore/explore.do?structureId=2NSEhttp://www.rcsb.org/pdb/explore/explore.do?structureId=2NSE 4.http://www.jbc.org/content/279/36/37918.long 5.http://www.brenda-enzymes.org/enzyme.php?ecno=1.14.13.39

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