1. 03/06/021 K 305 2 June 03

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4. 4 Vascular Smooth Muscle Cells Endothelium Neural Other Tissues Intrinsic Factors Regulation of Flow (Q)

5. 03/06/025 Vascular Smooth Muscle Cells Endothelium Neural Other Tissues Intrinsic Factors Regulation of Flow (Q)

6. 03/06/026 Vascular Smooth Muscle Cells Endothelium Nitric Oxide Endothelin EDRF Regulation of Flow (Q)

7. 03/06/027 Nitric Oxide NO (EDRF) synthesized in endothelial cells by NOS NOS stimulated by elevated [Ca 2+ ] i NOS converts arginine to NO NO freely permeates out of endothelial cell into VSM In VSM stimulates guanylyl cyclase increasing cGMP cGMP activates PKG which stimulates: SERCA (through phospholamban) and PMCA Reduces [Ca 2+ ] i - relaxation - VASODILATION vasodilator drugs nitroglycerin and nitroprusside

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9. 9 Nitric Oxide – Ca 2+ independent Activates GC in VSM to stimulate PKG PKG prevents Rho A from being activated Prevents inhibition of MLC Phosphatase Dephosporylates MLK Induces relaxation in VSM - VASODILATION

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12. 03/06/0212 Vascular Smooth Muscle Cells Endothelium Nitric Oxide Endothelin EDRF Regulation of Flow (Q)

13. 03/06/0213 Vascular Smooth Muscle Cells Endothelium Neural Other Tissues Intrinsic Factors Regulation of Flow (Q)

14. 03/06/0214 Vascular Smooth Muscle Cells Neural NA –  adrenergic receptor NA –  adrenergic receptor ACh – muscarinic receptor Regulation of Flow (Q)

15. 03/06/0215 Vascular Smooth Muscle Cells Endothelium Neural Other Tissues Intrinsic Factors Regulation of Flow (Q)