1. Development of a Wearable, Wireless, NIR* Imaging Device Rowan University Biosensors Lab Linda M. Head PhD, Faculty Director Rane Pierson BSECE, MS Student Undergraduate Students: Jessica Donovan, Andrew Flanyak, Michael McDonald *Near InfraRed

2. OUTLINE A.Uses of fNIR B.Our goals C.Progress to date D.Future work E.Acknowledgements F.References 11/17/08 New Jersey Technology Council Mid Atlantic Imaging Symposium 2

3. APPLICATIONS OF NIR SENSING & IMAGING TECHNIQUES 11/17/08 New Jersey Technology Council Mid Atlantic Imaging Symposium 3 Figure 1: Hb and HbO 2 absorption spectra [1] 1.Absorption of radiation by Hb and HbO 2 exceeds absorption by H 2 O at NIR wavelengths. [1] 2.Medical applications for near-infrared have proliferated into areas of blood analyte monitoring and imaging of materials including tissue. [2,3] 3.Specific applications include: a)Oximetry – measurement of O 2 levels in the blood (e.g. pulse oximetry) [4] b)Non-invasive assessment of brain function [5] c)In-vivo muscle metabolism measurement [6]

4. GOALS FOR ROWAN NIR IMAGING PROJECT Integrated electronics Custom package Reconfigurable FPGA-based control and data processing Wireless portability 11/17/08 New Jersey Technology Council Mid Atlantic Imaging Symposium 4 Figure 2: Modular Concept Drawing Fully modular and programmable NIR sensor.

5. STATE OF THE PROJECT: INTEGRATED ELECTRONICS Prototype component- based version of control system completed. – λ designation – Sampling rate – Noise suppression – Data storage & transmission Spartan3 development board prototype. 11/17/08 New Jersey Technology Council Mid Atlantic Imaging Symposium 5 Figure 3: Component-Based Board layout

6. STATE OF THE PROJECT: SENSOR NIR LED with 4 programmable settings: – dark – 730 nm – 805 nm – 850 nm OPT101 Photodiode detector Customizable package with embedded flexible circuit http://www.youtube.com/watch?v=j5SYnL0bh50 11/17/08 New Jersey Technology Council Mid Atlantic Imaging Symposium 6 Figure 5: Version1, Molded Rubber Sensor Assembly Figure 4: EPITEX NIR LED Specifications

7. STATE OF THE PROJECT: WIRELESS SOLUTION Goal is a single chip solution that can be embedded in the individual sensor modules – Single unit/multiple sensor – custom design – Multiple unit/multiple sensor – modular design Wireless network solutions required Development board in use for design prototypes 11/17/08 New Jersey Technology Council Mid Atlantic Imaging Symposium 7 Figure 6: Radiotronix RK-Wi232-DTS-R [7]

8. FUTURE PLANS 11/17/08 New Jersey Technology Council Mid Atlantic Imaging Symposium 8 Jr/Sr “Clinic” Thesis Project Product Development Sensor Package Wireless Network Project Planning FPGA Solutions Phantom Production Prototype ProductionTesting/Verification Funding Proposals Data Analysis Solution Conference Presentations

9. ACKNOWLEDGEMENTS Initial project conceived in collaboration with the Functional Optical Brain Imaging group at Drexel University. Funding provided by Rowan Dean’s Research Fund, Electrical & Computer Engineering program. Dr Sachin Shetty for conversations on wireless networks. Drs. Ramachandran and Tang for allowing undergraduates to miss class today! 11/17/08 New Jersey Technology Council Mid Atlantic Imaging Symposium 9

10. REFERENCES 1.http://www.biop.dk/Research/Main_research_tweezers.htmhttp://www.biop.dk/Research/Main_research_tweezers.htm 2.http://www.spectroscopynow.com/coi/cda/detail.cda&id=1881&type=EducationFeature&c hId=2&page=1#Refshttp://www.spectroscopynow.com/coi/cda/detail.cda&id=1881&type=EducationFeature&c hId=2&page=1#Refs 3.E. Ciurczak and J. Drennen, Near-Infrared Spectroscopy in Pharmaceutical and Medical Applications, Marcel-Dekker, Inc. New York, 2002. 4.Yoshiya I, Shimada Y, Tanaka K. Spectrophotometric monitoring of arterial oxygen in the fingertip. Med Biol Eng Comput 1980;18:27-32 5.Wolf M, et al. Progress of near infrared spectroscopy and imaging instrumentation for brain and muscle clinical applications. J. Biomed. Opt. 2007; 12, 062104. Review 6.Yuanqing Lin,a) Gwen Lech, Shoko Nioka, Xavier Intes, and Britton Chance, Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light- emitting diode continuous-wave imager. Review of Scientific Instruments, Vol. 73, No. 8, August 2002. 7.http://www.radiotronix.com/products/proddb.asp?ProdID=12http://www.radiotronix.com/products/proddb.asp?ProdID=12 11/17/08 New Jersey Technology Council Mid Atlantic Imaging Symposium 10