1. Integrated Biomedical Information for Better Health Workprogramme 2005-2006 Call 4 IST Conference- Networking Session

2. NEXT NEXT 10 years (2003-2014) PAST PAST 10 years (1991-2002) FP 2 FP 3 FP 4 FP 5 Computer Applications for Doctors Telemedicine systems and services Budget 20M € Budget 100M € Budget 140M € Budget 200M € Projects 30 Projects 63 Projects 158 Projects 125 Results Feasibility Study Results AIM Community Results 1 st batch of Products Results EU Health Telematics Industry @ 20 Years of eHealth R&D Context Regional Health Info Networks Home-care systems Personal Health Systems Health Knowledge Infostructure & HealthGrid Decision Support Systems Biomedical Informatics – support to Molecular and genomics Medicine Personal health systems (Wearable & Implantable) based on biosensors www.cordis.lu/ist/directorate_c/ehealth/index.html FP6 Research activities

3. Background to call 4 Vast amounts of information is collected and published related to 1) Individuals’ health status (confidential information) phenomic/clinical data” i) “phenomic/clinical data” (clinical info, info collected from in vitro/vivo diagnostics based on imaging and new biosensors, e.g. wearable/implantable systems) genomic data ii) “genomic data” – obtained from biochips 2) Human Health(public information) (medical knowledge, clinical research, public health knowledge & research, functional genomics, proteomics, environmental effects on health, nutrition, EMF, …)

4. Background to call 4 Biomedical information is collected, stored and processed on / in 1)Different Levels 1)Different Levels – (molecule, cell, tissue, organ, person, population) 2)Different Context - 2)Different Context - (care, research, education, policy/management) 3)Different Representation 3)Different Representation – (format, structures, ontologies) 4)Many many different places - Medical info resources (health records, personal/wearable health systems, clinical research databases, drug/pharma databases, NLM, …) - Public health info resources (epidemiological data and studies, national and WHO databases on diseases, …) - Biomolecular Info resources (DNA & protein sequences, microrarray data, protein interactions, human genome annotations..) - Environmental/Chemical/Biodiversity info resources

5. Synthesis of all “Health Information levels” Integrating biomedical data for better health Bioinformatics Medical Imaging Medical Informatics Public Health Informatics

6. Objectives of Call 4 process and integratebiomedical information from different levels and from many different places To support research and development of ICT based systems that process and integrate all possible relevant biomedical information from different levels and from many different places with the purpose to improve 1. Health knowledge discovery and understanding 2. Health status of an individual, i.e to improve disease prevention, diagnosis, treatment It is less about developing new technologies ( e.g. wearable monitoring systems) and more about optimal utilization of existing relevant information resources (data, signals, knowledge)

7. Scope of Call 4 Focus 1: Methods and systems for improved medical knowledge understanding through integration and processing of biomedical information Examples: - patient specific computational models of anatomy and physiology for disease modeling and simulation from molecular level to organ level e.g. new approaches to drug discoveries -methods to map and seamlessly link clinical and genetic information resources e.g. using grid technologies, electronic health records including genetic information - ICT methods for “in vivo” visualisation of biological processes on molecular level (ICT in support of molecular imaging)

8. Scope of Call 4 Focus 2: Innovative systems and services for disease prevention, diagnosis and treatment based on integrated biomedical information. Examples: - patient safety e.g. prevention of drug adverse effects - support to development of new “personalised” drug and/or nutrition - training tools for health professionals - improvements to diagnostic methods e.g. molecular imaging

9. Scope of Call 4 ALL proposals must point or show: measurable benefits, respect legal & ethical guidelines IPs: should address both focus 1 and 2 and should address the issue of integration and interoperability STREP: should focus on development of innovative system or service with clearly specified problem and target group

10. Scope of Call 4 Calling for roadmaps (Specific Support Measures) that lead to - recommendations for an R&D actions on EU level - should also consider other aspects ( legal, industrial, financial) -should indicate beneficial intermediate milestones i)Interoperability of eHealth systems – realistic approaches to this concept with clinical applicability. Special emphasis on semantic interoperability and the further R&D needed in the area of biomedical ontologies ii)In silico model of human being (virtual or physiological human) from eCell to eOrgan. Should indicate possible realistic and exploitable milestones e.g. each 3-4 years. iii) beneficial uptake of HealthGrid technologies and applications