1. NA-MIC National Alliance for Medical Image Computing http://na-mic.org Dartmouth Brain Imaging Laboratory & Indiana University Center for Neuroimaging Site PI: Andrew J. Saykin, Psy.D. http://synapse.hitchcock.org

2. National Alliance for Medical Image Computing http://na-mic.org Research Team Andrew Saykin, Psy.D. Robert Roth, Ph.D. Laura Flashman, Ph.D. Thomas McAllister, M.D. Nancy Koven, Ph.D. Jo Cara Pendergrass, Ph.D. John West, M.S. Heather Pixley, B.A. John MacDonald, M.A. Tara McHugh, M.A.

3. National Alliance for Medical Image Computing http://na-mic.org BIL Impact on NAMIC Provide Data (structural, functional, and diffusion MRI) Diffusion Data (1.5T): 6 Healthy controls (HC, older adults) 14 healthy controls and 13 patients with schizophrenia Structural Data (SPGR volumes, 1.5T): 6 healthy older adult controls 15 patients with schizophrenia – volumes plus 8 frontal subregions (left & right) Functional Data (1.5T): - Auditory-verbal n-back Working Memory Task 20 patients with schizophrenia, 20 healthy controls - Verbal Episodic Encoding/Recognition Task 6 healthy older adult controls 14 patients with schizophrenia, 9 healthy controls 3T: Sample DTI, structural & functional MR data on the same participants Influencing tool and algorithm design based on User feedback (e.g., 3D Slicer Editor, DTI module, fMRI module, user interface) Study demands (e.g., Multi modality integration, automated gray matter parcellation) Testing tools and algorithms developed within NAMIC

4. National Alliance for Medical Image Computing http://na-mic.org Interactions with Cores 1 & 2 JHU Testing of PAR to NRRD conversion tool to allow conversion of Philips DTI data to compatible Slicer format UNCShape analysis pipeline MGH DTI path of interest algorithm, Training and improvement of Slicer Editor, Processing pipeline for new Philips 3T data

5. National Alliance for Medical Image Computing http://na-mic.org Examples of NAMIC Success Stories Tracing of Multiple Gray Matter Structures Multi-modality Correlation of Structure and Function Left Hippocampus Right Hippocampus

6. National Alliance for Medical Image Computing http://na-mic.org Publications and Presentations NA-MIC Enabled Journal Articles Flashman, L.A., Roth, R.M., Cleavinger, H.B., Pixley, H.S., McAllister, T.W., Saykin, A.J., & Vidaver, R.M. (in press). Cavum septum pellucidum in schizophrenia: Symptom and neuropsychological correlates. Psychiatry Research: Neuroimaging. Roth, R.M., Saykin, A.J., Flashman, L.A., Pixley, H.S., West, J.D., Mamourian, A.C. (in press). Event-Related fMRI of Response Inhibition in Obsessive- Compulsive Disorder. Biological Psychiatry. McHugh, T.L., Saykin, A.J., Wishart, H.A., Flashman, L.A., Cleavinger, H.B., Rabin, L.A., Mamourian, A.C., Shen, L. (in press). Hippocampal Volume and Shape Analysis in an Older Adult Population. The Clinical Neuropsychologist.

7. National Alliance for Medical Image Computing http://na-mic.org Publications and Presentations Journal Articles cont. Wishart, H.A., Saykin, A.J., McAllister, T.W., Rabin, L.A., McDonald, B.C., Flashman, L.A., Roth, R.M., Mamourian, A.C., Tsongalis, G.J., Rhodes, C.H. Regional brain atrophy in cognitively intact adults with a single APOE epsilon4 allele. Neurology. 67(5):834-42, Sept. 12, 2006. Saykin, A.J., Wishart, H.A., Rabin, L.A., Santulli, R.B.,Flashman, L.A., West, J.D., McHugh, T.L., Mamourian, A.C. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology. 67(7):1221-4, Oct. 10, 2006. Roth RM, Koven NS, Randolph JJ, Flashman LA, Pixley HS, Ricketts SM, Wishart HA, Saykin AJ. Functional magnetic resonance imaging of executive control in bipolar disorder. Neuroreport. 17(11):1085-1089, July 31, 2006.

8. National Alliance for Medical Image Computing http://na-mic.org Publications and Presentations Submitted Articles Roth, R.M., Koven, N.S., Pendergrass, J.C., Flashman, L.A., & Saykin, A.J. (submitted). Apathy and the processing of novelty in schizophrenia. Koven, N.S., Roth, R.M., Pendergrass, J.C., Flashman, L.A., McAllister, T.W., Saykin, A.J. (submitted). Contribution of semantic clustering strategy to verbal learning and memory in schizophrenia.

9. National Alliance for Medical Image Computing http://na-mic.org Publications and Presentations Abstracts and Conference Proceedings West, J., Saykin, A., Roth, R., Flashman, L., Koven, N., Pendergrass, J.C., Arfanakis, K. (2007). Hippocampal and frontal memory circuitry abnormalities in schizophrenia: Relation of diffusion, morphometric and fMRI markers. Submitted to the 13th Annual Meeting of the Organization for Human Brain Mapping, Chicago, June. Flashman, L.A., Roth, R.M., McAllister, T.W., Pendergrass, J.C., Garlinghouse, M.A., & Saykin, A.J. (2007). Dissociation of awareness of different components of illness in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February. Koven, N.S., Roth, R.M., Buzzuto, L., Pendergrass, J.C., Flashman, L.A., & Saykin, A.J. (2007). Impact of reaction time variability on brain activation during working memory in schizophrenia. Poster to be presented at the 35th Annual Meeting of the International Neuropsychological Society, Portland, February.

10. National Alliance for Medical Image Computing http://na-mic.org Publications and Presentations Abstracts and Conference Proceedings cont. Roth, R.M., Flashman, L.A., Koven, N.S., Pendergrass, J.C., Garlinghouse, M.A.,* McAllister, T.W., & Saykin, A.J. (2007). Subjective integrity of working memory is related to brain activation during an N-back task in schizophrenia. Poster to be presented at the 18th Annual Meeting of the American Neuropsychiatric Association, Tucson, February. Koven, N.S., Roth, R.M., Flashman, L.A., Randolph, J.J., Pixley, H.S., Ricketts, S.M., Wishart, H.A., & Saykin, A.J. (2006). Relationship between mood and brain activation during executive control in bipolar I disorder: Poster presented at the 34th Annual Meeting of the International Neuropsychological Society, Boston, February. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society, 230. Rosen, A., Roth, R.M., Wishart, H.A., McDonald, B.C., Mac Donald, J., Flashman, L.A., Fadul, C., Kasper, L., Mamourian, A., & Saykin, A.J. (2006). Fornix volume in relapsing-remitting multiple sclerosis. Proceedings of the 34th Annual Meeting of the International Neuropsychological Society.

11. National Alliance for Medical Image Computing http://na-mic.org NAMIC Impact on the BIL General Impact Join a new network of computer science and engineering collaborators Opportunity as clinical neuroscience investigators to help steer the development of a major toolkit and gain a detailed appreciation of the tool development process New or enhanced interactions with other teams of clinical investigators working on multimodality neuroimaging studies in relationship to genetic and phenotypic variables Training: Dartmouth --> Bates, BYU, CUNY, ECSU; now IU

12. National Alliance for Medical Image Computing http://na-mic.org NAMIC Impact on the BIL Specific Impact New platform for morphometric analyses and ROI demarcation (Slicer 3 will permit replacing legacy tools with future-oriented platform) DTI processing pipeline for new 3T data - much faster than previous software/approach - integration of tractography with other modalities Integration of fMRI and DTI connectivity data - Path of Interest (POI) algorithm/implementation Potential for automated segmentation of deep gray matter structures using EM-segmenter

13. National Alliance for Medical Image Computing http://na-mic.org Future Impact of NAMIC Lasting impact at Dartmouth, Indiana University and destinations of post-doc training program graduates Extension of NAMIC collaborations via new grant proposals currently in planning stages Application of NAMIC tools to molecular imaging data sets and translational research including small animal imaging Application to clinical problems including surgical planning Application of Slicer to render physical 3D models for training and potential use in treatment planning