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Health Interventions:Evaluation of Cost Effectiveness Dr Sanjay Dixit M.D. Ph.D Diploma in Health System Management(U.S.A.) MGM Medical College Indore.

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Presentation on theme: "Health Interventions:Evaluation of Cost Effectiveness Dr Sanjay Dixit M.D. Ph.D Diploma in Health System Management(U.S.A.) MGM Medical College Indore."— Presentation transcript:

1 Health Interventions:Evaluation of Cost Effectiveness Dr Sanjay Dixit M.D. Ph.D Diploma in Health System Management(U.S.A.) MGM Medical College Indore

2 Health care interventions. Health system with similar level of Health expenditure per capita show wide variations in population health outcomes Some system devote resources to expensive interventions with small effect on population health

3 Health Care Interventions Low cost interventions with potentially greater benefit are not fully implemented Information on both costs and effectiveness are essential for making evidence-based decisions about competing health care interventions

4 Health Care Interventions 20 years ago Health Care intervention were centered exclusively on Clinical Effectiveness and not on Cost Effectiveness. Intervening years have seen an ever increasing strain on health resources. Therefore need of Economic Evaluation of health Interventions

5 Health Interventions… Clinical Behavioral Environmental Systems

6 What is problem ? How much problem can be prevented? How much problem intervention can prevented ? Benefits compare to costs ? What is cost of intervention How benefit to cost can compare What are Gain compare to present status? Key Question Decision makers Ask ?

7 Why Do Cost Effectiveness? Understand trade-offs between costs and benefits Inform decision makers

8 Cost effectiveness Analysis.. It is a Technique for identifying the most effective use of limited resource It compares alternative interventions/procedure/program using cost and a common effectiveness out come(Lives saved/cases prevented/additional days of activity/extent of sight restored/ Heart attacks avoided).

9 Cost effectiveness Analysis These are combined ( cost per heart attack avoided) such that the relative cost effectiveness can be assessed Used to assess the comparative impacts of expenditure on different health interventions.

10 Cost Effectiveness Analysis A study evaluating whether hypertension screening,Nutrition Counseling,Medication,or by pass surgery would provide the most additional years of life for each Ruppes spent is a Cost effectiveness study

11 Cost Effectiveness Analysis Cost Effectiveness of interventions such as DOTS for tuberculosis is highly cost-effective Liver transplant for alcoholic cirrhosis is highly cost-ineffective

12 Cost Effectiveness Analysis… It also helps to choose between medical and non medical approaches for protecting health such as better emergency medical services versus better highway design

13 Cost Effectiveness: What is it ? Cost Effectiveness = What you pay What you get

14 Burden of illness Deaths (mortality) Frequency (incidence, prevalence) Severity (disability, quality of life) Hospitalizations

15 Burden of Illness HEALTH IMPACT ECONOMIC IMPACT

16 Cost of illness Cost of Illness Direct (medical and non-medical) costs Indirect (productivity/Travel Expenses/Loss of time) costs Loss of Quality of Life Intangible costs (grief, pain, suffering)

17 Burden of Illness Cost of Illness HEALTH IMPACT ECONOMIC IMPACT

18 Can an Intervention Work? Interventions -- public health programs, policies, clinical care Efficacy Can an intervention work in ideal settings?

19 Effectiveness/Efficiency Effectiveness Relate input and output to out come..Are the outputs produced actually having desired impact Efficiency Indicates how inputs are used to produced the outputs

20 Burden of Illness Cost of Illness Net Benefit Intervention Effectiveness HEALTH IMPACT ECONOMIC IMPACT

21 Cost of Intervention? Net Cost (or Saving) = Cost of program + (Cost of care with a program – Cost of care without a program)

22 Burden of Illness Cost of Illness Net Benefit Cost of Program Difference in Cost of Care Net Cost Intervention Effectiveness HEALTH IMPACT ECONOMIC IMPACT

23 How Do Benefits Compare to Costs? Combine benefits, harms, and costs Cost effectiveness, cost utility, cost benefit

24 Does an Intervention Work? Effectiveness Does it work in real-world settings? Net Benefit = Benefits - Harms

25 Measuring Effectiveness Natural health units –Lives saved, cases prevented, life years saved Conversion to common units –Quality-adjusted life years (QALY’s) Conversion to Rupees

26 Quality of Life Adjustment Factors Duration Health Status Adjustment Reference State Perfect Health 1.00 3 months home confinement,TB 0.68 3 months home confinement contagious ds. 0.65 3 months depression 0.44 8 years kidney transplant 0.58 8 years mastectomy for breast cancer 0.48 life home dialysis 0.40 life hospital confinement contagious ds 0.16 Reference State Dead 0.00

27 Burden of Illness Cost of Illness Net Benefit Cost of Program Difference in Cost of Care Net Cost Intervention Effectiveness Cost Effectiveness HEALTH IMPACT ECONOMIC IMPACT

28 Steps in Cost-Effectiveness Analysis…. Step 1 Define the Program * Define Precisely problems to be analyzed, Its focus,process,and limits * Develop Alternative approaches to the program Treatment v/s Immunization, Refinement1 Age of Vaccination, Means of delivery Step 2 Compute net cost (Four Parts) * Compute gross Program cost Screening 1Cost of Screening, 2Follow up of +ve cases3,Treatment of person who otherwise might gone untreated * Compute monetary savings ( Cost of Avoided treatment) * Discount costs and saving to the present value (5 to 15 %) * Compute the net cost( Gross costs less savings)

29 Steps in Cost Effectiveness Analysis…. Step 3 Compute the net health effects Live saved, Complications averted, Cases of illness prevented ( in terms of additional years of healthy life). - Add Additional years with full health - Additional years of disease( A year restricted to home may be valued 80% of complete health -

30 Steps in Cost Effectiveness Analysis…. Improvements in health( not extension of life) like owns symptoms/restrictions of being home bound may be relieved - Negative effects (Inconveniences and morbidity) restricted activities/person has to visit the physicians office/Asthma relief

31 Step 4 Apply a decision rule based on Net Cost and net health effect Net Effects Net Cost Positive Net Cost Zero or Negative Positive Case 1 C.E.= Net Cost-Net Health Effects Case 2 Program economically Valuable Select most efficient program for Should generally be implemented Improving the health inexpensive and highly effective ( lowest Ratio ) Provision of safe water Measure of efficiency Immunization, iodization of salt Zero Case 3 Program benefit offset by morbidity Case 4 C.E. = Net Cost-Net Health Effects or and inconvenience. Program generally Select most efficient program Negative should not be implemented for containing costs( Highest ratio) Cost money worsening the life

32 Steps in Cost Effectiveness analysis… Step 5. Perform Sensitivity Analysis. It will be necessary to make number of assumptions and to estimate the value of various parameters. Sensitivity Analysis can be used to test how robust the results are to these imprecise measurements It is process used to predict exactly the future discount rate

33 Years ------ 1- 2 345Tot al Costs 10080752520300 Discount ed costs (5%) 10076682216 Benefits 1050758085300 Discount ed Benefits( 5%) 1048686970 DISCOUNTED COST/ BENEFIT

34 Sensitivity Analysis…. Opinion differ about the value of year with impaired health relative to perfect health Medical experts are uncertain about the value of various preventive measure. Professional assessment are constantly updated with research Its difficult to predict future discount rate

35 Sensitivity Analysis…. In sensitivity analysis areas of uncertainty are varied and the effect on result is noted Uncertain factors are to be examined and their effect on decision rule are studied If final decision is not affected by making different assumptions about uncertain quantities-by choosing High and Low estimates, than intervention may be applied If the decision would drastically altered by different estimates, than we should be cautious for making the recommendations

36 Step I Define the Program Hypothetical Influenza Inoculation Program Vaccinations would be administered to 100,000persons aged 65years and older over next year in existing clinics and health centers

37 Step II Compute Net Costs Inoculations (100,000X$3) = $300,000 Treatment of Reaction(50X$300)=+$15000(Plus) _________ Gross Program cost $315,000 Saving due to People not $–50,000 (Minus) getting influenza ____________ (1,000x$50) Net Program COST = $265,000

38 Step 3 Compute net Health Effects Type of effect Healthy Years ____________________________________________ 1 Additional healthy Life( 10X6.9) 67.9 2 Health Improvement for those Spared +40.0(Plus) Morbidity of influenza(1000X.04) ___________ Gross Health Effect 107.9 Negative effect of Adverse reaction -4.5 (Minus) (50X.09) _____________ Net Health Effect 103.4

39 Step IV Apply Decision Rule Case 1 Situation definite health gains are achieved but at net positive cost Net Cost divided by net health gain $265000/103.4 health years=$2563 per healthy years This ratio helps decision makers to determine whether to implement the program or not

40 Step 5 Perform Sensitivity analysis If expert think that only 800 cases of influenza will be prevented The cost effectiveness ratio will be increased Decision makers will decide whether its affordable Cost or Not to save life and provide healthy life years

41 Policy Implications of Economic Evaluations Type of AnalysisDenominatorPolicy Level Cost EffectivenessNatural Health Units (Life years saved, cases prevented) Specific Health Program Cost UtilityCommon Health Units (Quality-adjusted life year) Across health programs Cost BenefitRupees (all converted to Rupees) Across Sectors

42 Preliminary List of Services Scoring 8 or Higher

43 When to undertake the C.E.A. Formal C.E.A. analysis will be most useful when 1. Large amount of resources(Rs in Millions/Billions) are involved 2. Responsibilities for decisions are fragmented 3. The Goals and Objectives of different groups are at odd or unclear

44 When to undertake the C.E.A... 4.Alternate course of actions are radically different 5.The technology and risks underlying each alternatives are well understood 6. A long time frame is involved(eg Strategy versus management)

45 Use of Cost Effectiveness Analysis for Decision/Policy Makers Cost-effectiveness analysis as one tool decision-makers can use to assess and potentially improve the performance of their health system. It indicates which intervention provide the highest “value of money” and help them choose the interventions and programme which maximize health for available resources.

46 Challenges of CEA. Resource allocation decision affecting the entire health sector must take into account Priority of sick,reducing social inequalities in health or well being of future generation. Fails to identify existing misallocation of resources by focusing on evaluation of new technologies or strategies

47 Challenges of CEA.. The result of many CEA studies are context- specific,they cannot be used in other population There are difficulties of generalizing context specific CEA studies Overall effectiveness of a given clinical intervention is often not known

48 References Economics for Health Sector Analysis Concept and causes Mead Over The World Bank Washington D.C. Health Economics Fundamentals and Flow of funds Thomas E.Geten John Wiley & Sons (1997) Health Economics Theories,Insight Rexford E Sanrerre Revised Edition Dryden press Drden (2000) Development of WHO Guidelines on Generalized cost effectiveness analysis Christopher et.al Health Economics 9:235-251 (2000) Methods of Economic Evaluation of Health Care programmeDrummondMF et.a Second Edition Oxford University Press(1997) Health interventions assessment WHO –CHOICE website

49 THANK YOU

50 Cost Utility Analysis Life years saved are not homogenous Medical intervention is associated with significant number of life saved but a reduced quality of life. Another analysis “ Utility Analysis”has been frequently used in recent years.

51 Cost Utility Analysis Cost Utility analysis compares interventions(Procedure, test or method) using costs and health out come that is adjusted for quality of life as rated as assessed by the recipient- the patients ( For example Quality- Adjusted Life Years or QALYs. The ‘Common Currency’commonly used is QALYs,

52 Cost Utility….. A procedure with a 0.5 Quality of life outcome(QOL) or Quality adjusted life year (QALY) costing Rs 4000 equals in C-U analysis as Rs 8000 with QOL result of 0.25

53 Quality of Life adjustment Factors… It adjust number of life years gained by an index between 0.00 (Death) and 1.00 ( Good Health) Respondents indicated that living for three months confined to hospital for tuberculosis treatment was worth only 1.8months ( 0.60 x 3 months) Some people consider some illness to be worse than death, such additional years lived in such misery may has negative value

54 Method to construct index for measuring utility First Method:Asks people who have same condition to assess the quality of their lives Second Method:Describes the condition to a group of people who do not have the condition and ask them to gauge the quality of life or utility

55 Cost Utility….. Quality adjusted life years QALYs for each Health state and treatment was assessed by ‘Self Reported description’ Five dimensions are assessed Mobility,Self Care,Performance of usual activity, Pain/Discomfort,and Anxiety/Depression

56 Cost Utility… Each having three possible responses No problem/some difficulties/moderate problem/unable /Extreme problem Each combination has an associated utility value derived with a scale indexed between 0 ( dead) and 1 ( Full Health)

57 Cost utility analysis The difficulty in using utility analysis lies in developing appropriate index for measuring the Utility

58 Economic Issues-- Time Horizon Time frame should be long enough to capture all harms, benefits and costs regardless of when they occur, usually a lifetime Contrast with short term analyses which often capture many of the costs but fewer of the benefits

59 Economic Issues--Perspective Whose point of view -- patient, medical care system, employers, society

60 Examples of cost included in typical Cost effectiveness analysis based on perspective of analysis

61 Cost Benefit Analysis Cost Benefit Analysis (CBA) measures both cost and benefits in monetary values.An intervention is commonly adopted if the monetary benefits exceed the cost, resulting in net benefit. Important tool is the benefit -to-costs ratio Total Monetary cost of benefit or outcome divided by the total monetary cost of obtaining them

62 Cost –minimization Analysis The simplest from of economic evaluation where the procedure or programmer identified that cost the least. If there is no significant difference in the benefit of two interventions,the preferred intervention will be the one that is least costly If there is no significant difference in the cost of two interventions,the preferred intervention will be one that is most effective


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