1. Activity 3: Testing Medicines: A Clinical Trial Key Vocab: Clinical Trial, Control, Evidence, Placebo, Sample Size, Simulate/Simulation, Trade-Off Copy Data Table from Pg. A-13 under “data” section

2. Lesson Objective You will simulate a clinical trial to investigate how medicines are tested. * A simulation is an experience that is meant to mimic, or be like, another experience.

3. Procedures for Activity Let’s Discuss. Imagine the following: You work for a company that develops medicines. You have developed a medication for severe headaches and have tested it on rats and mice to see if it has any negative effects. The tests on animals showed no harmful effects, even at much higher doses than you plan to use on humans. Now it is time to test the medicine on human volunteers in a clinical trial. What could happen to these volunteers after they take the medicine? How would you test the medicine to be sure it is safe and improves the health of headache patients?

4. Procedure for Activity cont. Read Intro and Challenge Question. What is this activity about? Read the Procedure. What do you have to do during this activity? Please be sure to fill in your data as you work. When you are finished, share your results with the group. When I direct you, please share your results with the class. Work on Analysis 1, 2, and 3

5. Class Data Cup #Same as yellow drinkBetter than yellow drink Worse than yellow drink 13 23 331 413 513 6211 721 84 Total11135

6. Data for our class Same as Yellow Lemon Drink (Headache the same) Better than Yellow Lemon Drink (Headache Better) Worse than Yellow Lemon Drink (Headache Better) Control Group (received placebo) 824 Treatment Group (Received Medicine) 3111

7. Data for All Classes Same as Yellow Lemon Drink (Headache the same) Better than Yellow Lemon Drink (Headache Better) Worse than Yellow Lemon Drink (Headache better, but side effects) Control Group (received placebo) 26225 Treatment Group (Received Medicine) 8523

8. Graphing your data Complete the graphs on the bottom of student sheet 3.1 Create a graph for ALL CLASSES on a separate sheet of graph paper Be sure to follow APPENDIX A: ELEMENTS OF A GOOD GRAPH For your explanation, compare the data between your class (you can even talk about your specific group) and all classes. How are they similar? How are they different? If this were a real medication, would you recommend someone using it? Use the data to help you answer this question.