1. Chapter 2: Chemical Basis of Life

2. Elements In the Human Body
Major Elements Symbol Percentage in body Oxygen O 65% Carbon C 18.5% Hydrogen H 9.5% Nitrogen N 3.2 Calcium Ca 1.5 Phosphorus P 1.0 Potassium K 0.4 Sulfur S 0.3 Chlorine Cl 0.2 Sodium Na 0.2 Magnesium Mg 0.1

3. 2.3 Chemical Constituents of Cell
Organic – contain carbon and hydrogen atoms. Inorganic – molecules that does not contain carbon and hydrogen. Inorganic substances dissolve in water or react with water to release ions --- called electrolytes.

4. Inorganic Substances
Water, oxygen, carbon dioxide, and salts. Water: -major component of blood. -important solvent -aqueous portion of blood carries vital substances such as oxygen, sugars, salts, and vitamins, from the organs of digestion and respiration to the body cells.

5. Oxygen
Transported throughout the body by the blood. RBC bind and carry oxygen. Cells use oxygen to release energy from teh sugar glucose and other nutrients. Energy drives the cell’s metabolic activities.

6. Carbon Dioxide
CO2 Produced as a waste product when certain metabolic processes release energy, and it is exhaled from the lungs.

7. Salts
Compound composed of oppositely-charged ions. Na+ and Cl NaCl salt Salts provide necessary ions: Na+, Cl-, K+, Ca+2… Ions are important in metabolic processes. Transport of substances into and out of cells, muscle contraction, and nerve impulse conduction.

8. Review questions How do inorganic and organic molecules differ?
Organic contains hydrogen and carbon.
Inorganic doesn’t contain both hydrogen and carbon.
How do electrolytes and nonelectrolytes differ?
Inorganic substances that dissolve in water and release ions are called electrolytes ---organic substances that dissolve in water do not release ions and are called nonelectrolytes.

9. Organic Substances
Carbohydrates Lipids Proteins Nucleic Acids

10. Carbohydrates
Provide much of the energy that cells require. Used to build cell structures. Stored energy. Molecules: Carbon, hydrogen, and oxygen (twice as many hydrogen than oxygen atoms)

11. C6H12O6 glucose

12. Sugars
Carbohydrates with shorter chains.
monosaccharides

13. Complex Carbohydrates
Disaccharides – double sugars. - sucrose, lactose. Polysaccharides – many simple sugars joined. - plant starch - glycogen

15. Lipids Organic substances that are insoluble in water.
Soluble in certain organic solvents.
Ex. Fats, phospholipids, steroids

16. Fats Store energy for cellular activities.
Can supply more energy per gram than carbohydrate molecules.
Molecules:
Carbon, hydrogen and oxygen
-have a much smaller proportion of oxygen atoms than do carbs.

17. Fatty acids and glycerol
Building blocks of fat molecules.
Each glycerol molecule bonds with three fatty acid molecules to produce a single fat. (triglyceride)
Glycerol portions of all fat molecules are the same but the fats are diverse because there are many kinds of fatty acids.

19. Saturated vs. Unsaturated
Sing carbon-carbon bones –saturated fatty acid. Each carbon atom is bound to as many hydrogen atoms as possible. Other fatty acid chains do not have the max number of hydrogen atoms bound to it. Have one or more double bonds of carbon molecules. –unsaturated Saturated and unsaturated fats.

20. Phospholipid
Phospholipid – contains a glycerol portion and two fatty acid chains and a phosphate group.
Phosphate group is
soluble in water.
(hydrophilic)
Fatty acid portion is
insoluble in water.
(hydrophobic)

21. Steroids Complex structures with four connected rings of carbon atoms.
Ex. Estrogen, progesterone, testosterone..

22. Proteins Energy source Hormones Structural materials
Glycoproteins – found on cell surfaces as receptors that bond with certain molecules.
Antibodies – detect and destroy foreign substances in the body.
Enzymes – catalyzes reactions.

23. Amino acids Building blocks of protein.
Contain: Nitrogen, sometimes sulfur
-NH2 (amino group)
-COOH (carboxyl group)
-R group (this distinguishes what type of amino acid it is)

24. 20 different amino acids Polypeptide chain
Structure: primary, secondary, and tertiary levels.
Conformation: 3-d shape
Conformation determines its function.
Types:
Long and fibrous – keratin, forms hair
Globular – enzymes, ion channels, carrier proteins.

26. Denatured
When hydrogen bonds in a protein break because of excessive heat, radiation, electricity, pH changes, other chemicals.
Ex. Heat denatures the protein in egg white (albumin), changing it from a liquid to a solid.

27. Nucleic Acids Form genes and take part in protein synthesis.
Contain: Carbon, Hydrogen, Oxygen, Nitrogen, and Phosphorus
Nucleotides: ribose or deoxyribose, phosphate group, nitrogenous bases.

28. 2 types RNA (ribonucleic acid) DNA (deoxyribonucleic acid)
Adenosine triphosphate (ATP) – provide energy to certain chemical reactions.

29. Prions Type of protein that can cause disease.
Ex. mad cow disease, Creutzfeldt-Jakob disease